Tissue expression of ROS1 - Summary - The Human Protein Atlas

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ROS1

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ROS1
Gene description	ROS proto-oncogene 1 , receptor tyrosine kinase
Protein class	Cancer-related genes Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (epididymis, lung)
GTEx:	Tissue enriched (lung)
FANTOM5:	Group enriched (epididymis, lung)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA049098
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (epididymis, lung)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (lung)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (epididymis, lung)

GENE INFORMATION
Gene name	ROS1 (HGNC Symbol)
Synonyms	c-ros-1, MCF3, ROS
Description	ROS proto-oncogene 1 , receptor tyrosine kinase (HGNC Symbol)
Entrez gene summary	This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q22.1
Chromosome location (bp)	117288300 - 117425855
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000047936 (version 83.38)
Entrez gene	6098
UniProt	P08922 (UniProt - Evidence at protein level)
neXtProt	NX_P08922
Antibodypedia	ROS1 antibodies

PROTEIN BROWSER

ROS1-001	ROS1-002	ROS1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ROS1-001 ENSP00000357494 ENST00000368508	P08922 [Direct mapping] Proto-oncogene tyrosine-protein kinase ROS Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0002066 [columnar/cuboidal epithelial cell development] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007283 [spermatogenesis] GO:0008283 [cell proliferation] GO:0009986 [cell surface] GO:0010629 [negative regulation of gene expression] GO:0010966 [regulation of phosphate transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016049 [cell growth] GO:0019903 [protein phosphatase binding] GO:0023014 [signal transduction by protein phosphorylation] GO:0030154 [cell differentiation] GO:0032006 [regulation of TOR signaling] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0048471 [perinuclear region of cytoplasm] GO:0070372 [regulation of ERK1 and ERK2 cascade] Show all	2347 aa 263.9 kDa	Yes	1
ROS1-002 ENSP00000357493 ENST00000368507	Q5H8Y1 [Direct mapping] Tyrosine-protein kinase receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] Show all	2341 aa 263.3 kDa	Yes	1
ROS1-003 ENSP00000384647 ENST00000403284	H0Y3T9 [Direct mapping] Proto-oncogene tyrosine-protein kinase ROS Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0005515 [protein binding] Show all	97 aa 11.1 kDa	No	0

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