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TNFRSF17

GENERAL INFORMATION

Gene name

 TNFRSF17

Gene description

 Tumor necrosis factor receptor superfamily, member 17

Protein class

 Cancer-related genes
CD markers
Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (Karpas-707, RPMI-8226, U-266/70, U-266/84)
HPA (normal tissue):Tissue enhanced (tonsil)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable) and breast cancer (favourable).
Head and neck cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 TNFRSF17 (HGNC Symbol)

Synonyms

 BCM, BCMA, CD269, TNFRSF13A

Description

 Tumor necrosis factor receptor superfamily, member 17 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 p13.13

Chromosome location (bp)

 11965107 - 11968068

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000048462 (version 83.38)

Entrez gene

 608

UniProt

 Q02223 (UniProt - Evidence at protein level)

neXtProt

 NX_Q02223

Antibodypedia

 TNFRSF17 antibodies

PROTEIN BROWSER
TNFRSF17-001
TNFRSF17-002
TNFRSF17-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNFRSF17-001
ENSP00000053243
ENST00000053243
Q02223 [Direct mapping]
Tumor necrosis factor receptor superfamily member 17
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
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GO:0002250 [adaptive immune response]
GO:0002260 [lymphocyte homeostasis]
GO:0004872 [receptor activity]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0012505 [endomembrane system]
GO:0016021 [integral component of membrane]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
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 184 aa
20.2 kDa 		No 1
TNFRSF17-002
ENSP00000454314
ENST00000562385
H3BMB5 [Direct mapping]
Tumor necrosis factor receptor superfamily member 17
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
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GO:0016021 [integral component of membrane]
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 133 aa
14.9 kDa 		No 1
TNFRSF17-003
ENSP00000379753
ENST00000396495
Q02223 [Direct mapping]
Tumor necrosis factor receptor superfamily member 17
Show all
CD markers
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Show all
GO:0002250 [adaptive immune response]
GO:0004872 [receptor activity]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0012505 [endomembrane system]
GO:0016021 [integral component of membrane]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
Show all
 135 aa
14.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.