Granular cytoplasmic expression in placental trophoblasts and ovarian follicle cells.
ANTIBODY IHC RELIABILITY
Data reliability description
Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding in intestine observed and disregarded.
Most thyroid cancers showed moderate cytoplasmic immunoreactivity. Remaining cancer tissues were negative.
ADAMTS6 (HGNC Symbol)
ADAM metallopeptidase with thrombospondin type 1 motif, 6 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. [provided by RefSeq, Jul 2008]