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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ADAMTS6
  • premium

    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ADAMTS6

Gene description

ADAM metallopeptidase with thrombospondin type 1 motif, 6

Protein class

Cancer-related genes
Enzymes
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (HBF TERT88, TIME, U-2197)
HPA (normal tissue):Tissue enhanced (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in placental trophoblasts and ovarian follicle cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding in intestine observed and disregarded.

Reliability score

Supported based on 1 antibody.
HPA043441
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA043441

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most thyroid cancers showed moderate cytoplasmic immunoreactivity. Remaining cancer tissues were negative.

GENE INFORMATION

Gene name

ADAMTS6 (HGNC Symbol)

Synonyms

ADAM-TS6

Description

ADAM metallopeptidase with thrombospondin type 1 motif, 6 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q12.3

Chromosome location (bp)

65148736 - 65481920

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000049192 (version 83.38)

Entrez gene

11174

UniProt

Q9UKP5 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9UKP5

Antibodypedia

ADAMTS6 antibodies

PROTEIN BROWSER

ADAMTS6-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAMTS6-007
ENSP00000370443
ENST00000381055
Q9UKP5 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 6
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Enzymes
   Peptidases
   Metallopeptidases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
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GO:0003279 [cardiac septum development]
GO:0004222 [metalloendopeptidase activity]
GO:0005578 [proteinaceous extracellular matrix]
GO:0006508 [proteolysis]
GO:0007507 [heart development]
GO:0008233 [peptidase activity]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0031012 [extracellular matrix]
GO:0035904 [aorta development]
GO:0060976 [coronary vasculature development]
Show all
1117 aa
125.3 kDa
Yes 0

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