Expression of ADAMTS6 in cancer - Summary

GENERAL INFORMATION
Gene name	ADAMTS6
Gene description	ADAM metallopeptidase with thrombospondin type 1 motif, 6
Protein class	Cancer-related genes Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HBF TERT88, TIME, U-2197)
HPA (normal tissue):	Tissue enhanced (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in placental trophoblasts and ovarian follicle cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding in intestine observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA043441
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA043441

GENE INFORMATION
Gene name	ADAMTS6 (HGNC Symbol)
Synonyms	ADAM-TS6
Description	ADAM metallopeptidase with thrombospondin type 1 motif, 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q12.3
Chromosome location (bp)	65148736 - 65481920
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000049192 (version 83.38)
Entrez gene	11174
UniProt	Q9UKP5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UKP5
Antibodypedia	ADAMTS6 antibodies

PROTEIN BROWSER

ADAMTS6-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAMTS6-007 ENSP00000370443 ENST00000381055	Q9UKP5 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 6 Show all	Enzymes Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Show all	GO:0003279 [cardiac septum development] GO:0004222 [metalloendopeptidase activity] GO:0005578 [proteinaceous extracellular matrix] GO:0006508 [proteolysis] GO:0007507 [heart development] GO:0008233 [peptidase activity] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] GO:0035904 [aorta development] GO:0060976 [coronary vasculature development] Show all	1117 aa 125.3 kDa	Yes	0