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ADAMTS6

GENERAL INFORMATION

Gene name

 ADAMTS6

Gene description

 ADAM metallopeptidase with thrombospondin type 1 motif, 6

Protein class

 Cancer-related genes
Enzymes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (placenta)
GTEx:Mixed
FANTOM5:Tissue enhanced (placenta)

Protein evidence

 Evidence at protein level

Protein expression

 Granular cytoplasmic expression in placental trophoblasts and ovarian follicle cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding in intestine observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA043441
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (placenta)

GENE INFORMATION

Gene name

 ADAMTS6 (HGNC Symbol)

Synonyms

 ADAM-TS6

Description

 ADAM metallopeptidase with thrombospondin type 1 motif, 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q12.3

Chromosome location (bp)

 65148736 - 65481920

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000049192 (version 83.38)

Entrez gene

 11174

UniProt

 Q9UKP5 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9UKP5

Antibodypedia

 ADAMTS6 antibodies

PROTEIN BROWSER
ADAMTS6-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADAMTS6-007
ENSP00000370443
ENST00000381055
Q9UKP5 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 6
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Enzymes
   Peptidases
   Metallopeptidases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Show all
GO:0003279 [cardiac septum development]
GO:0004222 [metalloendopeptidase activity]
GO:0005578 [proteinaceous extracellular matrix]
GO:0006508 [proteolysis]
GO:0007507 [heart development]
GO:0008233 [peptidase activity]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0031012 [extracellular matrix]
GO:0035904 [aorta development]
GO:0060976 [coronary vasculature development]
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 1117 aa
125.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.