Expression of ARID1B in cancer - Summary - The Human Protein Atlas

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ARID1B

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ARID1B
Gene description	AT rich interactive domain 1B (SWI1-like)
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly nuclear expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA016511
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (unfavourable) and ovarian cancer (unfavourable).
Breast cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA016511

GENE INFORMATION
Gene name	ARID1B (HGNC Symbol)
Synonyms	6A3-5, BAF250b, DAN15, ELD/OSA1, KIAA1235, p250R
Description	AT rich interactive domain 1B (SWI1-like) (HGNC Symbol)
Entrez gene summary	This locus encodes an AT-rich DNA interacting domain-containing protein. The encoded protein is a component of the SWI/SNF chromatin remodeling complex and may play a role in cell-cycle activation. The protein encoded by this locus is similar to AT-rich interactive domain-containing protein 1A. These two proteins function as alternative, mutually exclusive ARID-subunits of the SWI/SNF complex. The associated complexes play opposing roles. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2012]
Chromosome	6
Cytoband	q25.3
Chromosome location (bp)	156777374 - 157210779
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000049618 (version 83.38)
Entrez gene	57492
UniProt	Q8NFD5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NFD5
Antibodypedia	ARID1B antibodies

PROTEIN BROWSER

ARID1B-001	ARID1B-003	ARID1B-004	ARID1B-005	ARID1B-006	ARID1B-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARID1B-001 ENSP00000344546 ENST00000346085	Q8NFD5 [Direct mapping] AT-rich interactive domain-containing protein 1B Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0007399 [nervous system development] GO:0016514 [SWI/SNF complex] GO:0048096 [chromatin-mediated maintenance of transcription] GO:0071565 [nBAF complex] GO:0090544 [BAF-type complex] Show all	2249 aa 237.7 kDa	No	0
ARID1B-003 ENSP00000488727 ENST00000478761		Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] Show all	306 aa 31.9 kDa	No	0
ARID1B-004 ENSP00000313006 ENST00000319584	H0Y2R3 [Direct mapping] AT-rich interactive domain-containing protein 1B Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	728 aa 76.2 kDa	No	0
ARID1B-005 ENSP00000412835 ENST00000414678	H0Y7H8 [Direct mapping] AT-rich interactive domain-containing protein 1B Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006338 [chromatin remodeling] GO:0090544 [BAF-type complex] Show all	1758 aa 190.7 kDa	No	0
ARID1B-006 ENSP00000383596 ENST00000400790	H0Y3S9 [Direct mapping] AT-rich interactive domain-containing protein 1B Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] Show all	273 aa 29.5 kDa	No	0
ARID1B-009 ENSP00000055163 ENST00000350026	Q8NFD5 [Direct mapping] AT-rich interactive domain-containing protein 1B Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0007399 [nervous system development] GO:0016514 [SWI/SNF complex] GO:0048096 [chromatin-mediated maintenance of transcription] GO:0090544 [BAF-type complex] Show all	2236 aa 236.1 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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