Cell atlas - CLPTM1L - The Human Protein Atlas

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CLPTM1L

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	CLPTM1L
Gene description	CLPTM1-like
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA014791
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA014791	A-431	Endoplasmic reticulum
	HPA014791	U-2 OS	Endoplasmic reticulum
	HPA014791	U-251 MG	Endoplasmic reticulum

GENE INFORMATION
Gene name	CLPTM1L (HGNC Symbol)
Synonyms	CRR9, FLJ14400
Description	CLPTM1-like (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a membrane protein whose overexpression in cisplatin-sensitive cells causes apoptosis. Polymorphisms in this gene have been reported to increase susceptibility to several cancers, including lung, pancreatic, and breast cancers. [provided by RefSeq, Nov 2015]
Chromosome	5
Cytoband	p15.33
Chromosome location (bp)	1317744 - 1345099
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000049656 (version 83.38)
Entrez gene	81037
UniProt	Q96KA5 (UniProt - Evidence at protein level)
neXtProt	NX_Q96KA5
Antibodypedia	CLPTM1L antibodies

PROTEIN BROWSER

CLPTM1L-001	CLPTM1L-008	CLPTM1L-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLPTM1L-001 ENSP00000313854 ENST00000320895	Q96KA5 [Direct mapping] Cleft lip and palate transmembrane protein 1-like protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006915 [apoptotic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	538 aa 62.2 kDa	No	6
CLPTM1L-008 ENSP00000423321 ENST00000507807	G5E9Z2 [Direct mapping] Cisplatin resistance related protein CRR9p, isoform CRA_c; Cleft lip and palate transmembrane protein 1-like protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006915 [apoptotic process] GO:0016021 [integral component of membrane] Show all	369 aa 43.3 kDa	No	3
CLPTM1L-201 ENSP00000485923 ENST00000630539	G5E9Z2 [Direct mapping] Cisplatin resistance related protein CRR9p, isoform CRA_c; Cleft lip and palate transmembrane protein 1-like protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006915 [apoptotic process] GO:0016021 [integral component of membrane] Show all	369 aa 43.3 kDa	No	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.