Expression of CLPTM1L in cancer - Summary - The Human Protein Atlas

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CLPTM1L

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CLPTM1L
Gene description	CLPTM1-like
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Antibody staining in cells/structures not annotated, view images.
Reliability score	Approved based on 1 antibody. HPA014791
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014791

GENE INFORMATION
Gene name	CLPTM1L (HGNC Symbol)
Synonyms	CRR9, FLJ14400
Description	CLPTM1-like (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a membrane protein whose overexpression in cisplatin-sensitive cells causes apoptosis. Polymorphisms in this gene have been reported to increase susceptibility to several cancers, including lung, pancreatic, and breast cancers. [provided by RefSeq, Nov 2015]
Chromosome	5
Cytoband	p15.33
Chromosome location (bp)	1317744 - 1345099
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000049656 (version 83.38)
Entrez gene	81037
UniProt	Q96KA5 (UniProt - Evidence at protein level)
neXtProt	NX_Q96KA5
Antibodypedia	CLPTM1L antibodies

PROTEIN BROWSER

CLPTM1L-001	CLPTM1L-008	CLPTM1L-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLPTM1L-001 ENSP00000313854 ENST00000320895	Q96KA5 [Direct mapping] Cleft lip and palate transmembrane protein 1-like protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006915 [apoptotic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	538 aa 62.2 kDa	No	6
CLPTM1L-008 ENSP00000423321 ENST00000507807	G5E9Z2 [Direct mapping] Cisplatin resistance related protein CRR9p, isoform CRA_c; Cleft lip and palate transmembrane protein 1-like protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006915 [apoptotic process] GO:0016021 [integral component of membrane] Show all	369 aa 43.3 kDa	No	3
CLPTM1L-201 ENSP00000485923 ENST00000630539	G5E9Z2 [Direct mapping] Cisplatin resistance related protein CRR9p, isoform CRA_c; Cleft lip and palate transmembrane protein 1-like protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006915 [apoptotic process] GO:0016021 [integral component of membrane] Show all	369 aa 43.3 kDa	No	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.