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MAPK9

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GENERAL INFORMATION

Gene name

 MAPK9

Gene description

 Mitogen-activated protein kinase 9

Protein class

 Enzymes
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 MAPK9 (HGNC Symbol)

Synonyms

 JNK2, p54a, PRKM9, SAPK

Description

 Mitogen-activated protein kinase 9 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]

Chromosome

 5

Cytoband

 q35.3

Chromosome location (bp)

 180233143 - 180292099

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000050748 (version 83.38)

Entrez gene

 5601

UniProt

 P45984 (UniProt - Evidence at protein level)

neXtProt

 NX_P45984

Antibodypedia

 MAPK9 antibodies

PROTEIN BROWSER
MAPK9-001
MAPK9-002
MAPK9-003
MAPK9-004
MAPK9-005
MAPK9-006
MAPK9-012
MAPK9-201
MAPK9-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAPK9-001
ENSP00000394560
ENST00000452135
P45984 [Direct mapping]
Mitogen-activated protein kinase 9
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001836 [release of cytochrome c from mitochondria]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004705 [JUN kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006626 [protein targeting to mitochondrion]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006950 [response to stress]
GO:0007254 [JNK cascade]
GO:0007258 [JUN phosphorylation]
GO:0007417 [central nervous system development]
GO:0008134 [transcription factor binding]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0009612 [response to mechanical stimulus]
GO:0009636 [response to toxic substance]
GO:0010033 [response to organic substance]
GO:0010628 [positive regulation of gene expression]
GO:0010744 [positive regulation of macrophage derived foam cell differentiation]
GO:0010770 [positive regulation of cell morphogenesis involved in differentiation]
GO:0014075 [response to amine]
GO:0031175 [neuron projection development]
GO:0031394 [positive regulation of prostaglandin biosynthetic process]
GO:0031396 [regulation of protein ubiquitination]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0032308 [positive regulation of prostaglandin secretion]
GO:0032722 [positive regulation of chemokine production]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0034644 [cellular response to UV]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042493 [response to drug]
GO:0042752 [regulation of circadian rhythm]
GO:0043065 [positive regulation of apoptotic process]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045087 [innate immune response]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046328 [regulation of JNK cascade]
GO:0046686 [response to cadmium ion]
GO:0048511 [rhythmic process]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0051770 [positive regulation of nitric-oxide synthase biosynthetic process]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071803 [positive regulation of podosome assembly]
GO:2001235 [positive regulation of apoptotic signaling pathway]
Show all
 424 aa
48.1 kDa 		No 0
MAPK9-002
ENSP00000345524
ENST00000343111
P45984 [Direct mapping]
Mitogen-activated protein kinase 9
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004705 [JUN kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007254 [JNK cascade]
GO:0008134 [transcription factor binding]
GO:0010628 [positive regulation of gene expression]
GO:0010744 [positive regulation of macrophage derived foam cell differentiation]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042752 [regulation of circadian rhythm]
GO:0045087 [innate immune response]
GO:0048511 [rhythmic process]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
Show all
 382 aa
44.2 kDa 		No 0
MAPK9-003
ENSP00000377028
ENST00000393360
P45984 [Direct mapping]
Mitogen-activated protein kinase 9
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004705 [JUN kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007254 [JNK cascade]
GO:0008134 [transcription factor binding]
GO:0010628 [positive regulation of gene expression]
GO:0010744 [positive regulation of macrophage derived foam cell differentiation]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042752 [regulation of circadian rhythm]
GO:0045087 [innate immune response]
GO:0048511 [rhythmic process]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
Show all
 382 aa
44.1 kDa 		No 0
MAPK9-004
ENSP00000389338
ENST00000455781
P45984 [Direct mapping]
Mitogen-activated protein kinase 9
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004705 [JUN kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007254 [JNK cascade]
GO:0008134 [transcription factor binding]
GO:0010628 [positive regulation of gene expression]
GO:0010744 [positive regulation of macrophage derived foam cell differentiation]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042752 [regulation of circadian rhythm]
GO:0045087 [innate immune response]
GO:0048511 [rhythmic process]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
Show all
 424 aa
48.3 kDa 		No 0
MAPK9-005
ENSP00000397422
ENST00000425491
P45984 [Direct mapping]
Mitogen-activated protein kinase 9
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004705 [JUN kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007254 [JNK cascade]
GO:0008134 [transcription factor binding]
GO:0010628 [positive regulation of gene expression]
GO:0010744 [positive regulation of macrophage derived foam cell differentiation]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042752 [regulation of circadian rhythm]
GO:0045087 [innate immune response]
GO:0048511 [rhythmic process]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
Show all
 242 aa
27.3 kDa 		No 0
MAPK9-006
ENSP00000321410
ENST00000347470
J3KNK1 [Direct mapping]
Mitogen-activated protein kinase 9
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
Show all
 339 aa
38.2 kDa 		No 0
MAPK9-012
ENSP00000430608
ENST00000523583
E5RJ57 [Direct mapping]
Mitogen-activated protein kinase 9
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 104 aa
11.7 kDa 		No 0
MAPK9-201
ENSP00000380262
ENST00000397072
D7R528 [Direct mapping]
Mitogen-activated protein kinase 9; Mitogen-activated protein kinase 9 isoform JNK2 alpha 4
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
Show all
 124 aa
13.7 kDa 		No 0
MAPK9-202
ENSP00000443149
ENST00000539014
D7R525 [Direct mapping]
Mitogen-activated protein kinase 9; Mitogen-activated protein kinase 9 isoform JNK2 gamma 2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
Show all
 214 aa
24.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.