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The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]
P45984 [Direct mapping] Mitogen-activated protein kinase 9
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Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001836 [release of cytochrome c from mitochondria] GO:0001934 [positive regulation of protein phosphorylation] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004705 [JUN kinase activity] GO:0004707 [MAP kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0006626 [protein targeting to mitochondrion] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006950 [response to stress] GO:0007254 [JNK cascade] GO:0007258 [JUN phosphorylation] GO:0007417 [central nervous system development] GO:0008134 [transcription factor binding] GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0009612 [response to mechanical stimulus] GO:0009636 [response to toxic substance] GO:0010033 [response to organic substance] GO:0010628 [positive regulation of gene expression] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010770 [positive regulation of cell morphogenesis involved in differentiation] GO:0014075 [response to amine] GO:0031175 [neuron projection development] GO:0031394 [positive regulation of prostaglandin biosynthetic process] GO:0031396 [regulation of protein ubiquitination] GO:0031435 [mitogen-activated protein kinase kinase kinase binding] GO:0032308 [positive regulation of prostaglandin secretion] GO:0032722 [positive regulation of chemokine production] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0034644 [cellular response to UV] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0042493 [response to drug] GO:0042752 [regulation of circadian rhythm] GO:0043065 [positive regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045087 [innate immune response] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046328 [regulation of JNK cascade] GO:0046686 [response to cadmium ion] GO:0048511 [rhythmic process] GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] GO:0051403 [stress-activated MAPK cascade] GO:0051770 [positive regulation of nitric-oxide synthase biosynthetic process] GO:0071222 [cellular response to lipopolysaccharide] GO:0071347 [cellular response to interleukin-1] GO:0071356 [cellular response to tumor necrosis factor] GO:0071363 [cellular response to growth factor stimulus] GO:0071803 [positive regulation of podosome assembly] GO:2001235 [positive regulation of apoptotic signaling pathway]
P45984 [Direct mapping] Mitogen-activated protein kinase 9
Show all
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P45984 [Direct mapping] Mitogen-activated protein kinase 9
Show all
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P45984 [Direct mapping] Mitogen-activated protein kinase 9
Show all
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)