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BCAR1

GENERAL INFORMATION

Gene name

 BCAR1

Gene description

 Breast cancer anti-estrogen resistance 1

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 17
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 External characterization data supports antibody staining.

Reliability score

 Approved based on 2 antibodies.
HPA042282 , CAB000443
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), liver cancer (unfavourable) and lung cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA042282
CAB000443

GENE INFORMATION

Gene name

 BCAR1 (HGNC Symbol)

Synonyms

 CAS, CASS1, Crkas, P130Cas

Description

 Breast cancer anti-estrogen resistance 1 (HGNC Symbol)

Entrez gene summary

 BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM, May 2009]

Chromosome

 16

Cytoband

 q23.1

Chromosome location (bp)

 75228187 - 75268053

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000050820 (version 83.38)

Entrez gene

 9564

UniProt

 P56945 (UniProt - Evidence at protein level)

neXtProt

 NX_P56945

Antibodypedia

 BCAR1 antibodies

PROTEIN BROWSER
«
BCAR1-001
BCAR1-002
BCAR1-003
BCAR1-004
BCAR1-005
BCAR1-006
BCAR1-008
BCAR1-009
BCAR1-012
BCAR1-013
BCAR1-015
BCAR1-016
BCAR1-017
BCAR1-019
BCAR1-020
BCAR1-021
BCAR1-022
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BCAR1-001
ENSP00000377074
ENST00000393422
P56945 [Direct mapping]
Breast cancer anti-estrogen resistance protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0001726 [ruffle]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0016477 [cell migration]
GO:0017124 [SH3 domain binding]
GO:0019901 [protein kinase binding]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0042981 [regulation of apoptotic process]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0050851 [antigen receptor-mediated signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0050853 [B cell receptor signaling pathway]
GO:0051301 [cell division]
GO:0060326 [cell chemotaxis]
Show all
 888 aa
95.2 kDa 		No 0
BCAR1-002
ENSP00000162330
ENST00000162330
P56945 [Direct mapping]
Breast cancer anti-estrogen resistance protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0001726 [ruffle]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0016477 [cell migration]
GO:0017124 [SH3 domain binding]
GO:0019901 [protein kinase binding]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0042981 [regulation of apoptotic process]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0050851 [antigen receptor-mediated signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0050853 [B cell receptor signaling pathway]
GO:0051301 [cell division]
GO:0060326 [cell chemotaxis]
Show all
 870 aa
93.4 kDa 		No 0
BCAR1-003
ENSP00000392708
ENST00000420641
P56945 [Direct mapping]
Breast cancer anti-estrogen resistance protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0001726 [ruffle]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0016477 [cell migration]
GO:0017124 [SH3 domain binding]
GO:0019901 [protein kinase binding]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0042981 [regulation of apoptotic process]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0050851 [antigen receptor-mediated signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0050853 [B cell receptor signaling pathway]
GO:0051301 [cell division]
GO:0060326 [cell chemotaxis]
Show all
 888 aa
95.5 kDa 		No 0
BCAR1-004
ENSP00000443841
ENST00000538440
P56945 [Direct mapping]
Breast cancer anti-estrogen resistance protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0001726 [ruffle]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0016477 [cell migration]
GO:0017124 [SH3 domain binding]
GO:0019901 [protein kinase binding]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0042981 [regulation of apoptotic process]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0050851 [antigen receptor-mediated signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0050853 [B cell receptor signaling pathway]
GO:0051301 [cell division]
GO:0060326 [cell chemotaxis]
Show all
 870 aa
93.3 kDa 		No 0
BCAR1-005
ENSP00000391669
ENST00000418647
P56945 [Direct mapping]
Breast cancer anti-estrogen resistance protein 1
Show all
   SignalP predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0001726 [ruffle]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0017124 [SH3 domain binding]
GO:0019901 [protein kinase binding]
GO:0030027 [lamellipodium]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0042981 [regulation of apoptotic process]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0050851 [antigen receptor-mediated signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0050853 [B cell receptor signaling pathway]
GO:0051301 [cell division]
GO:0060326 [cell chemotaxis]
Show all
 916 aa
97.9 kDa 		No 0
BCAR1-006
ENSP00000440370
ENST00000535626
P56945 [Direct mapping]
Breast cancer anti-estrogen resistance protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0001726 [ruffle]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0016477 [cell migration]
GO:0017124 [SH3 domain binding]
GO:0019901 [protein kinase binding]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0042981 [regulation of apoptotic process]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0050851 [antigen receptor-mediated signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0050853 [B cell receptor signaling pathway]
GO:0051301 [cell division]
GO:0060326 [cell chemotaxis]
Show all
 722 aa
77.7 kDa 		No 0
BCAR1-008
ENSP00000377072
ENST00000393420
P56945 [Direct mapping]
Breast cancer anti-estrogen resistance protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0001726 [ruffle]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0016477 [cell migration]
GO:0017124 [SH3 domain binding]
GO:0019901 [protein kinase binding]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0042981 [regulation of apoptotic process]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0050851 [antigen receptor-mediated signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0050853 [B cell receptor signaling pathway]
GO:0051301 [cell division]
GO:0060326 [cell chemotaxis]
Show all
 888 aa
95.5 kDa 		No 0
BCAR1-009
ENSP00000440415
ENST00000542031
P56945 [Direct mapping]
Breast cancer anti-estrogen resistance protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0001726 [ruffle]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0008283 [cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0016477 [cell migration]
GO:0017124 [SH3 domain binding]
GO:0019901 [protein kinase binding]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0042981 [regulation of apoptotic process]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0050851 [antigen receptor-mediated signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0050853 [B cell receptor signaling pathway]
GO:0051301 [cell division]
GO:0060326 [cell chemotaxis]
Show all
 868 aa
93.1 kDa 		No 0
BCAR1-012
ENSP00000457097
ENST00000563323
H3BTB0 [Direct mapping]
Breast cancer anti-estrogen resistance protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 59 aa
6.2 kDa 		No 0
BCAR1-013
ENSP00000457457
ENST00000561970
H3BU42 [Direct mapping]
Breast cancer anti-estrogen resistance protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 80 aa
8.5 kDa 		No 0
BCAR1-015
ENSP00000457231
ENST00000567215
H3BTL5 [Direct mapping]
Breast cancer anti-estrogen resistance protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 50 aa
5.4 kDa 		No 0
BCAR1-016
ENSP00000456929
ENST00000566465
H3BSY4 [Direct mapping]
Breast cancer anti-estrogen resistance protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 128 aa
13.8 kDa 		No 0
BCAR1-017
ENSP00000454702
ENST00000569340
H3BN62 [Direct mapping]
Breast cancer anti-estrogen resistance protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 238 aa
25.5 kDa 		No 0
BCAR1-019
ENSP00000456625
ENST00000568864
H3BSB2 [Direct mapping]
Breast cancer anti-estrogen resistance protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 135 aa
14.4 kDa 		No 0
BCAR1-020
ENSP00000458088
ENST00000569006
H3BVF0 [Direct mapping]
Breast cancer anti-estrogen resistance protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 120 aa
12.8 kDa 		No 0
BCAR1-021
ENSP00000455810
ENST00000564028
H3BQJ7 [Direct mapping]
Breast cancer anti-estrogen resistance protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 133 aa
14.2 kDa 		No 0
BCAR1-022
ENSP00000442161
ENST00000546196
F5H855 [Direct mapping]
Breast cancer anti-estrogen resistance protein 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
Show all
 57 aa
5.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.