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THOC3

GENERAL INFORMATION

Gene name

 THOC3

Gene description

 THO complex 3

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA044009
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 THOC3 (HGNC Symbol)

Synonyms

 MGC5469, TEX1

Description

 THO complex 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of the nuclear THO transcription elongation complex, which is part of the larger transcription export (TREX) complex that couples messenger RNA processing and export. In humans, the transcription export complex is recruited to the 5'-end of messenger RNAs in a splicing- and cap-dependent manner. Studies of a related complex in mouse suggest that the metazoan transcription export complex is involved in cell differentiation and development. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, May 2013]

Chromosome

 5

Cytoband

 q35.2

Chromosome location (bp)

 175917873 - 176034680

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000051596 (version 83.38)

Entrez gene

 84321

UniProt

 Q96J01 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96J01

Antibodypedia

 THOC3 antibodies

PROTEIN BROWSER
THOC3-001
THOC3-002
THOC3-003
THOC3-004
THOC3-008
THOC3-010
THOC3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
THOC3-001
ENSP00000265097
ENST00000265097
Q96J01 [Direct mapping]
THO complex subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000346 [transcription export complex]
GO:0000445 [THO complex part of transcription export complex]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006397 [mRNA processing]
GO:0006406 [mRNA export from nucleus]
GO:0008380 [RNA splicing]
GO:0016607 [nuclear speck]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046784 [viral mRNA export from host cell nucleus]
Show all
 351 aa
38.8 kDa 		No 0
THOC3-002
ENSP00000425781
ENST00000515016
H0YA11 [Direct mapping]
THO complex subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 57 aa
6.1 kDa 		No 0
THOC3-003
ENSP00000394166
ENST00000432305
H7C0C5 [Direct mapping]
THO complex subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 75 aa
8.4 kDa 		No 0
THOC3-004
ENSP00000422243
ENST00000513482
Q96J01 [Direct mapping]
THO complex subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000346 [transcription export complex]
GO:0000445 [THO complex part of transcription export complex]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006397 [mRNA processing]
GO:0006406 [mRNA export from nucleus]
GO:0008380 [RNA splicing]
GO:0016607 [nuclear speck]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046784 [viral mRNA export from host cell nucleus]
Show all
 327 aa
36 kDa 		No 0
THOC3-008
ENSP00000424967
ENST00000505969
H0Y9T1 [Direct mapping]
THO complex subunit 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 56 aa
5.9 kDa 		No 0
THOC3-010
ENSP00000425039
ENST00000514861
D6REC9 [Direct mapping]
THO complex subunit 3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
Show all
 166 aa
18.4 kDa 		Yes 0
THOC3-201
ENSP00000487428
ENST00000628318
D6RGZ2 [Direct mapping]
THO complex subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 105 aa
11.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.