Tissue expression of FOXN3 - Summary - The Human Protein Atlas

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FOXN3

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	FOXN3
Gene description	Forkhead box N3
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic and nuclear expression.

DATA RELIABILITY
Data reliability description	Pending external verification. Antibody staining in cells/structures not annotated, view images.
Reliability score	Approved based on 1 antibody. HPA059209
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

Small intestine

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	FOXN3 (HGNC Symbol)
Synonyms	C14orf116, CHES1
Description	Forkhead box N3 (HGNC Symbol)
Entrez gene summary	This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband
Chromosome location (bp)	89124871 - 89619149
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000053254 (version 83.38)
Entrez gene	1112
UniProt	O00409 (UniProt - Evidence at protein level)
neXtProt	NX_O00409
Antibodypedia	FOXN3 antibodies

PROTEIN BROWSER

FOXN3-001	FOXN3-003	FOXN3-004	FOXN3-005	FOXN3-006	FOXN3-007	FOXN3-009	FOXN3-012	FOXN3-017	FOXN3-018	FOXN3-201	FOXN3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FOXN3-001 ENSP00000452227 ENST00000555353	O00409 [Direct mapping] Forkhead box protein N3 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0008022 [protein C-terminus binding] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	468 aa 51.5 kDa	No	0
FOXN3-003 ENSP00000343288 ENST00000345097	O00409 [Direct mapping] Forkhead box protein N3 A0A024R6I1 [Target identity:100%; Query identity:100%] Checkpoint suppressor 1, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0008022 [protein C-terminus binding] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	490 aa 53.8 kDa	No	0
FOXN3-004 ENSP00000452005 ENST00000557258	O00409 [Direct mapping] Forkhead box protein N3 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0008022 [protein C-terminus binding] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	468 aa 51.5 kDa	No	0
FOXN3-005 ENSP00000451135 ENST00000555855	G3V3A7 [Direct mapping] Forkhead box protein N3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	208 aa 23.4 kDa	No	0
FOXN3-006 ENSP00000451902 ENST00000553904	G3V4N5 [Direct mapping] Forkhead box protein N3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		54 aa 5.6 kDa	No	0
FOXN3-007 ENSP00000452290 ENST00000555034	G3V5C7 [Direct mapping] Forkhead box protein N3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		93 aa 10.1 kDa	No	0
FOXN3-009 ENSP00000450833 ENST00000553840	H0YJ54 [Direct mapping] Forkhead box protein N3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	185 aa 20 kDa	No	0
FOXN3-012 ENSP00000450684 ENST00000556916	H0YJ22 [Direct mapping] Forkhead box protein N3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	111 aa 12.7 kDa	No	0
FOXN3-017 ENSP00000452444 ENST00000553353	H0YJY0 [Direct mapping] Forkhead box protein N3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		122 aa 13.4 kDa	No	0
FOXN3-018 ENSP00000450783 ENST00000557572	H0YJ43 [Direct mapping] Forkhead box protein N3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		79 aa 8.9 kDa	No	0
FOXN3-201 ENSP00000261302 ENST00000261302	O00409 [Direct mapping] Forkhead box protein N3 A0A024R6I1 [Target identity:100%; Query identity:100%] Checkpoint suppressor 1, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0008022 [protein C-terminus binding] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	490 aa 53.8 kDa	No	0
FOXN3-202 ENSP00000479114 ENST00000615335	O00409 [Direct mapping] Forkhead box protein N3 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0008022 [protein C-terminus binding] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	468 aa 51.5 kDa	No	0

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The Human Protein Atlas

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