Cell atlas - FOXN3 - The Human Protein Atlas

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FOXN3

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Cytokinetic bridge
	Nucleus
	Plasma membrane

Human cell
	Microtubules
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	FOXN3
Gene description	Forkhead box N3
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus & plasma membrane. In addition localized to the cytokinetic bridge.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Plasma membrane (approved)
Additional location	In addition localized to the Cytokinetic bridge (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA059209
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus & plasma membrane. In addition localized to the cytokinetic bridge.

Main location

Nucleus (approved), Plasma membrane (approved)

Additional location

Cytokinetic bridge (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA059209	RH-30	Nucleus
			Plasma membrane
			Cytokinetic bridge	Intensity	Intensity
	HPA059209	RT4	Nucleus
	HPA059209	RT4	Plasma membrane
	HPA059209	U-2 OS	Nucleus
	HPA059209	U-2 OS	Plasma membrane

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition
Intensity variation	Cytokinetic bridge

GENE INFORMATION
Gene name	FOXN3 (HGNC Symbol)
Synonyms	C14orf116, CHES1
Description	Forkhead box N3 (HGNC Symbol)
Entrez gene summary	This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband
Chromosome location (bp)	89124871 - 89619149
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000053254 (version 83.38)
Entrez gene	1112
UniProt	O00409 (UniProt - Evidence at protein level)
neXtProt	NX_O00409
Antibodypedia	FOXN3 antibodies

PROTEIN BROWSER

FOXN3-001	FOXN3-003	FOXN3-004	FOXN3-005	FOXN3-006	FOXN3-007	FOXN3-009	FOXN3-012	FOXN3-017	FOXN3-018	FOXN3-201	FOXN3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FOXN3-001 ENSP00000452227 ENST00000555353	O00409 [Direct mapping] Forkhead box protein N3 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0008022 [protein C-terminus binding] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	468 aa 51.5 kDa	No	0
FOXN3-003 ENSP00000343288 ENST00000345097	O00409 [Direct mapping] Forkhead box protein N3 A0A024R6I1 [Target identity:100%; Query identity:100%] Checkpoint suppressor 1, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0008022 [protein C-terminus binding] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	490 aa 53.8 kDa	No	0
FOXN3-004 ENSP00000452005 ENST00000557258	O00409 [Direct mapping] Forkhead box protein N3 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0008022 [protein C-terminus binding] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	468 aa 51.5 kDa	No	0
FOXN3-005 ENSP00000451135 ENST00000555855	G3V3A7 [Direct mapping] Forkhead box protein N3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	208 aa 23.4 kDa	No	0
FOXN3-006 ENSP00000451902 ENST00000553904	G3V4N5 [Direct mapping] Forkhead box protein N3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		54 aa 5.6 kDa	No	0
FOXN3-007 ENSP00000452290 ENST00000555034	G3V5C7 [Direct mapping] Forkhead box protein N3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		93 aa 10.1 kDa	No	0
FOXN3-009 ENSP00000450833 ENST00000553840	H0YJ54 [Direct mapping] Forkhead box protein N3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	185 aa 20 kDa	No	0
FOXN3-012 ENSP00000450684 ENST00000556916	H0YJ22 [Direct mapping] Forkhead box protein N3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	111 aa 12.7 kDa	No	0
FOXN3-017 ENSP00000452444 ENST00000553353	H0YJY0 [Direct mapping] Forkhead box protein N3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		122 aa 13.4 kDa	No	0
FOXN3-018 ENSP00000450783 ENST00000557572	H0YJ43 [Direct mapping] Forkhead box protein N3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		79 aa 8.9 kDa	No	0
FOXN3-201 ENSP00000261302 ENST00000261302	O00409 [Direct mapping] Forkhead box protein N3 A0A024R6I1 [Target identity:100%; Query identity:100%] Checkpoint suppressor 1, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0008022 [protein C-terminus binding] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	490 aa 53.8 kDa	No	0
FOXN3-202 ENSP00000479114 ENST00000615335	O00409 [Direct mapping] Forkhead box protein N3 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0008022 [protein C-terminus binding] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	468 aa 51.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.