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AKR7A2

GENERAL INFORMATION

Gene name

 AKR7A2

Gene description

 Aldo-keto reductase family 7, member A2

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
CAB032587 , CAB032841
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB032587
CAB032841

GENE INFORMATION

Gene name

 AKR7A2 (HGNC Symbol)

Synonyms

 AFAR

Description

 Aldo-keto reductase family 7, member A2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. [provided by RefSeq, Oct 2011]

Chromosome

 1

Cytoband

 p36.13

Chromosome location (bp)

 19303965 - 19312146

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000053371 (version 83.38)

Entrez gene

 8574

UniProt

 O43488 (UniProt - Evidence at protein level)

neXtProt

 NX_O43488

Antibodypedia

 AKR7A2 antibodies

PROTEIN BROWSER
AKR7A2-001
AKR7A2-002
AKR7A2-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AKR7A2-001
ENSP00000235835
ENST00000235835
O43488 [Direct mapping]
Aflatoxin B1 aldehyde reductase member 2
V9HWA2 [Target identity:100%; Query identity:100%]
Aldo-keto reductase family 7, member A2 (Aflatoxin aldehyde reductase); Epididymis secretory sperm binding protein Li 166mP
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004032 [alditol:NADP+ 1-oxidoreductase activity]
GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0009055 [electron carrier activity]
GO:0019119 [phenanthrene-9,10-epoxide hydrolase activity]
GO:0044281 [small molecule metabolic process]
GO:0044597 [daunorubicin metabolic process]
GO:0044598 [doxorubicin metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 359 aa
39.6 kDa 		No 0
AKR7A2-002
ENSP00000339084
ENST00000330072
H3BLU7 [Direct mapping]
Aflatoxin B1 aldehyde reductase member 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 314 aa
34.7 kDa 		No 0
AKR7A2-007
ENSP00000419936
ENST00000489286
H7C5H7 [Direct mapping]
Aflatoxin B1 aldehyde reductase member 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 205 aa
21.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.