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AKR7A2

GENERAL INFORMATION

Gene name

 AKR7A2

Gene description

 Aldo-keto reductase family 7, member A2

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
CAB032587 , CAB032841
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 AKR7A2 (HGNC Symbol)

Synonyms

 AFAR

Description

 Aldo-keto reductase family 7, member A2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. [provided by RefSeq, Oct 2011]

Chromosome

 1

Cytoband

 p36.13

Chromosome location (bp)

 19303965 - 19312146

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000053371 (version 83.38)

Entrez gene

 8574

UniProt

 O43488 (UniProt - Evidence at protein level)

neXtProt

 NX_O43488

Antibodypedia

 AKR7A2 antibodies

PROTEIN BROWSER
AKR7A2-001
AKR7A2-002
AKR7A2-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AKR7A2-001
ENSP00000235835
ENST00000235835
O43488 [Direct mapping]
Aflatoxin B1 aldehyde reductase member 2
V9HWA2 [Target identity:100%; Query identity:100%]
Aldo-keto reductase family 7, member A2 (Aflatoxin aldehyde reductase); Epididymis secretory sperm binding protein Li 166mP
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004032 [alditol:NADP+ 1-oxidoreductase activity]
GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0009055 [electron carrier activity]
GO:0019119 [phenanthrene-9,10-epoxide hydrolase activity]
GO:0044281 [small molecule metabolic process]
GO:0044597 [daunorubicin metabolic process]
GO:0044598 [doxorubicin metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 359 aa
39.6 kDa 		No 0
AKR7A2-002
ENSP00000339084
ENST00000330072
H3BLU7 [Direct mapping]
Aflatoxin B1 aldehyde reductase member 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 314 aa
34.7 kDa 		No 0
AKR7A2-007
ENSP00000419936
ENST00000489286
H7C5H7 [Direct mapping]
Aflatoxin B1 aldehyde reductase member 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 205 aa
21.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.