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ARID4B

GENERAL INFORMATION

Gene name

 ARID4B

Gene description

 AT rich interactive domain 4B (RBP1-like)

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA027333
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027333

GENE INFORMATION

Gene name

 ARID4B (HGNC Symbol)

Synonyms

 BCAA, BRCAA1, RBP1L1, SAP180

Description

 AT rich interactive domain 4B (RBP1-like) (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q42.3

Chromosome location (bp)

 235131634 - 235328219

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000054267 (version 83.38)

Entrez gene

 51742

UniProt

 Q4LE39 (UniProt - Evidence at protein level)

neXtProt

 NX_Q4LE39

Antibodypedia

 ARID4B antibodies

PROTEIN BROWSER
ARID4B-001
ARID4B-004
ARID4B-006
ARID4B-007
ARID4B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARID4B-001
ENSP00000264184
ENST00000349213
Q4LE39 [Direct mapping]
AT-rich interactive domain-containing protein 4B
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008150 [biological_process]
GO:0010467 [gene expression]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045814 [negative regulation of gene expression, epigenetic]
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 1226 aa
137.6 kDa 		No 0
ARID4B-004
ENSP00000355562
ENST00000366603
Q4LE39 [Direct mapping]
AT-rich interactive domain-containing protein 4B
A0A024R3R1 [Target identity:100%; Query identity:100%]
AT rich interactive domain 4B (RBP1-like), isoform CRA_d
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008150 [biological_process]
GO:0010467 [gene expression]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045814 [negative regulation of gene expression, epigenetic]
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 1312 aa
147.8 kDa 		No 0
ARID4B-006
ENSP00000416063
ENST00000444620
H0Y7Y8 [Direct mapping]
AT-rich interactive domain-containing protein 4B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0044212 [transcription regulatory region DNA binding]
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 553 aa
61.4 kDa 		No 0
ARID4B-007
ENSP00000391497
ENST00000418304
X6RCR8 [Direct mapping]
AT-rich interactive domain-containing protein 4B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0044212 [transcription regulatory region DNA binding]
Show all
 483 aa
55.3 kDa 		No 0
ARID4B-201
ENSP00000264183
ENST00000264183
Q4LE39 [Direct mapping]
AT-rich interactive domain-containing protein 4B
A0A024R3R1 [Target identity:100%; Query identity:100%]
AT rich interactive domain 4B (RBP1-like), isoform CRA_d
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006325 [chromatin organization]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007283 [spermatogenesis]
GO:0008150 [biological_process]
GO:0010467 [gene expression]
GO:0034773 [histone H4-K20 trimethylation]
GO:0036124 [histone H3-K9 trimethylation]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0097368 [establishment of Sertoli cell barrier]
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 1312 aa
147.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.