Expression of PTPRN in cancer - Summary

GENERAL INFORMATION
Gene name	PTPRN
Gene description	Protein tyrosine phosphatase, receptor type, N
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (glioma, pancreatic cancer)
HPA (cell line):	Group enriched (U-2 OS, U-87 MG)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in islets of Langerhans, adrenal medulla and in neuronal cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA007179
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (unfavourable).
Glioma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (glioma, pancreatic cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA007179

GENE INFORMATION
Gene name	PTPRN (HGNC Symbol)
Synonyms	IA-2
Description	Protein tyrosine phosphatase, receptor type, N (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
Chromosome	2
Cytoband	q35
Chromosome location (bp)	219289623 - 219309648
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000054356 (version 83.38)
Entrez gene	5798
UniProt	Q16849 (UniProt - Evidence at protein level)
neXtProt	NX_Q16849
Antibodypedia	PTPRN antibodies

PROTEIN BROWSER

PTPRN-001	PTPRN-003	PTPRN-008	PTPRN-009	PTPRN-011	PTPRN-012	PTPRN-013	PTPRN-020	PTPRN-021

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTPRN-001 ENSP00000295718 ENST00000295718	Q16849 [Direct mapping] Receptor-type tyrosine-protein phosphatase-like N Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0000302 [response to reactive oxygen species] GO:0001553 [luteinization] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005768 [endosome] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006470 [protein dephosphorylation] GO:0008021 [synaptic vesicle] GO:0009749 [response to glucose] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0019221 [cytokine-mediated signaling pathway] GO:0030073 [insulin secretion] GO:0030141 [secretory granule] GO:0030507 [spectrin binding] GO:0032868 [response to insulin] GO:0035773 [insulin secretion involved in cellular response to glucose stimulus] GO:0043025 [neuronal cell body] GO:0043627 [response to estrogen] GO:0043679 [axon terminus] GO:0045202 [synapse] GO:0051020 [GTPase binding] GO:0051591 [response to cAMP] GO:1990502 [dense core granule maturation] Show all	979 aa 105.8 kDa	Yes	1
PTPRN-003 ENSP00000386638 ENST00000409251	Q16849 [Direct mapping] Receptor-type tyrosine-protein phosphatase-like N Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0000302 [response to reactive oxygen species] GO:0001553 [luteinization] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005768 [endosome] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006470 [protein dephosphorylation] GO:0008021 [synaptic vesicle] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0030073 [insulin secretion] GO:0030141 [secretory granule] GO:0030507 [spectrin binding] GO:0035773 [insulin secretion involved in cellular response to glucose stimulus] GO:0043025 [neuronal cell body] GO:0043679 [axon terminus] GO:0045202 [synapse] GO:1990502 [dense core granule maturation] Show all	950 aa 102.8 kDa	Yes	1
PTPRN-008 ENSP00000395379 ENST00000446182	C9JJL7 [Direct mapping] Receptor-type tyrosine-protein phosphatase-like N Show all	Predicted intracellular proteins Show all		125 aa 13.6 kDa	No	0
PTPRN-009 ENSP00000397105 ENST00000451506	C9J392 [Direct mapping] Receptor-type tyrosine-protein phosphatase-like N Show all	Predicted intracellular proteins Show all		67 aa 7.5 kDa	No	0
PTPRN-011 ENSP00000408036 ENST00000440552	C9JR27 [Direct mapping] Receptor-type tyrosine-protein phosphatase-like N Show all	Predicted intracellular proteins Show all		166 aa 18.1 kDa	No	0
PTPRN-012 ENSP00000388429 ENST00000412847	C9JJL7 [Direct mapping] Receptor-type tyrosine-protein phosphatase-like N Show all	Predicted intracellular proteins Show all		125 aa 13.6 kDa	No	0
PTPRN-013 ENSP00000396464 ENST00000442029	C9JCQ0 [Direct mapping] Receptor-type tyrosine-protein phosphatase-like N Show all	Predicted intracellular proteins Show all		86 aa 9.2 kDa	No	0
PTPRN-020 ENSP00000396842 ENST00000443981	H7C0U9 [Direct mapping] Receptor-type tyrosine-protein phosphatase-like N Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0006470 [protein dephosphorylation] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	137 aa 15.6 kDa	No	0
PTPRN-021 ENSP00000392598 ENST00000423636	Q16849 [Direct mapping] Receptor-type tyrosine-protein phosphatase-like N Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0000302 [response to reactive oxygen species] GO:0001553 [luteinization] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005768 [endosome] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006470 [protein dephosphorylation] GO:0008021 [synaptic vesicle] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0030073 [insulin secretion] GO:0030141 [secretory granule] GO:0030507 [spectrin binding] GO:0035773 [insulin secretion involved in cellular response to glucose stimulus] GO:0043025 [neuronal cell body] GO:0043679 [axon terminus] GO:0045202 [synapse] GO:1990502 [dense core granule maturation] Show all	889 aa 96.3 kDa	No	1