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PTPRN

GENERAL INFORMATION

Gene name

 PTPRN

Gene description

 Protein tyrosine phosphatase, receptor type, N

Protein class

 Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus, pituitary gland)
FANTOM5:Group enriched (brain, caudate, cerebellum, hippocampus, pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in islets of Langerhans, adrenal medulla and in neuronal cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA007179
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus, pituitary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus, pituitary gland)

GENE INFORMATION

Gene name

 PTPRN (HGNC Symbol)

Synonyms

 IA-2

Description

 Protein tyrosine phosphatase, receptor type, N (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

Chromosome

 2

Cytoband

 q35

Chromosome location (bp)

 219289623 - 219309648

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000054356 (version 83.38)

Entrez gene

 5798

UniProt

 Q16849 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16849

Antibodypedia

 PTPRN antibodies

PROTEIN BROWSER
PTPRN-001
PTPRN-003
PTPRN-008
PTPRN-009
PTPRN-011
PTPRN-012
PTPRN-013
PTPRN-020
PTPRN-021

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTPRN-001
ENSP00000295718
ENST00000295718
Q16849 [Direct mapping]
Receptor-type tyrosine-protein phosphatase-like N
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0001553 [luteinization]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0008021 [synaptic vesicle]
GO:0009749 [response to glucose]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030073 [insulin secretion]
GO:0030141 [secretory granule]
GO:0030507 [spectrin binding]
GO:0032868 [response to insulin]
GO:0035773 [insulin secretion involved in cellular response to glucose stimulus]
GO:0043025 [neuronal cell body]
GO:0043627 [response to estrogen]
GO:0043679 [axon terminus]
GO:0045202 [synapse]
GO:0051020 [GTPase binding]
GO:0051591 [response to cAMP]
GO:1990502 [dense core granule maturation]
Show all
 979 aa
105.8 kDa 		Yes 1
PTPRN-003
ENSP00000386638
ENST00000409251
Q16849 [Direct mapping]
Receptor-type tyrosine-protein phosphatase-like N
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0001553 [luteinization]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0008021 [synaptic vesicle]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0030073 [insulin secretion]
GO:0030141 [secretory granule]
GO:0030507 [spectrin binding]
GO:0035773 [insulin secretion involved in cellular response to glucose stimulus]
GO:0043025 [neuronal cell body]
GO:0043679 [axon terminus]
GO:0045202 [synapse]
GO:1990502 [dense core granule maturation]
Show all
 950 aa
102.8 kDa 		Yes 1
PTPRN-008
ENSP00000395379
ENST00000446182
C9JJL7 [Direct mapping]
Receptor-type tyrosine-protein phosphatase-like N
Show all
Predicted intracellular proteins
Show all
 125 aa
13.6 kDa 		No 0
PTPRN-009
ENSP00000397105
ENST00000451506
C9J392 [Direct mapping]
Receptor-type tyrosine-protein phosphatase-like N
Show all
Predicted intracellular proteins
Show all
 67 aa
7.5 kDa 		No 0
PTPRN-011
ENSP00000408036
ENST00000440552
C9JR27 [Direct mapping]
Receptor-type tyrosine-protein phosphatase-like N
Show all
Predicted intracellular proteins
Show all
 166 aa
18.1 kDa 		No 0
PTPRN-012
ENSP00000388429
ENST00000412847
C9JJL7 [Direct mapping]
Receptor-type tyrosine-protein phosphatase-like N
Show all
Predicted intracellular proteins
Show all
 125 aa
13.6 kDa 		No 0
PTPRN-013
ENSP00000396464
ENST00000442029
C9JCQ0 [Direct mapping]
Receptor-type tyrosine-protein phosphatase-like N
Show all
Predicted intracellular proteins
Show all
 86 aa
9.2 kDa 		No 0
PTPRN-020
ENSP00000396842
ENST00000443981
H7C0U9 [Direct mapping]
Receptor-type tyrosine-protein phosphatase-like N
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0006470 [protein dephosphorylation]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
Show all
 137 aa
15.6 kDa 		No 0
PTPRN-021
ENSP00000392598
ENST00000423636
Q16849 [Direct mapping]
Receptor-type tyrosine-protein phosphatase-like N
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0001553 [luteinization]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006470 [protein dephosphorylation]
GO:0008021 [synaptic vesicle]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0030073 [insulin secretion]
GO:0030141 [secretory granule]
GO:0030507 [spectrin binding]
GO:0035773 [insulin secretion involved in cellular response to glucose stimulus]
GO:0043025 [neuronal cell body]
GO:0043679 [axon terminus]
GO:0045202 [synapse]
GO:1990502 [dense core granule maturation]
Show all
 889 aa
96.3 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.