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NOP58

GENERAL INFORMATION

Gene name

 NOP58

Gene description

 NOP58 ribonucleoprotein

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct expression in the nuclei and nucleoli in most cell types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA018472 , HPA021062
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and ovarian cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA018472
HPA021062

GENE INFORMATION

Gene name

 NOP58 (HGNC Symbol)

Synonyms

 HSPC120, NOP5

Description

 NOP58 ribonucleoprotein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a core component of box C/D small nucleolar ribonucleoproteins. Some box C/D small nucleolar RNAs (snoRNAs), such as U3, U8, and U14, are dependent upon the encoded protein for their synthesis. This protein is SUMOylated, which is necessary for high affinity binding to snoRNAs. [provided by RefSeq, Nov 2015]

Chromosome

 2

Cytoband

 q33.1

Chromosome location (bp)

 202265716 - 202303666

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000055044 (version 83.38)

Entrez gene

 51602

UniProt

 Q9Y2X3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y2X3

Antibodypedia

 NOP58 antibodies

PROTEIN BROWSER
NOP58-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NOP58-001
ENSP00000264279
ENST00000264279
Q9Y2X3 [Direct mapping]
Nucleolar protein 58
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000154 [rRNA modification]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005732 [small nucleolar ribonucleoprotein complex]
GO:0005737 [cytoplasm]
GO:0006364 [rRNA processing]
GO:0006608 [snRNP protein import into nucleus]
GO:0015030 [Cajal body]
GO:0016020 [membrane]
GO:0016049 [cell growth]
GO:0030515 [snoRNA binding]
GO:0031428 [box C/D snoRNP complex]
GO:0032040 [small-subunit processome]
GO:0044822 [poly(A) RNA binding]
GO:0070761 [pre-snoRNP complex]
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 529 aa
59.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.