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EIF2AK2

GENERAL INFORMATION

Gene name

 EIF2AK2

Gene description

 Eukaryotic translation initiation factor 2-alpha kinase 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, including lymphoid organs.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA019795 , CAB003845
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable) and endometrial cancer (unfavourable).
Pancreatic cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019795
CAB003845

GENE INFORMATION

Gene name

 EIF2AK2 (HGNC Symbol)

Synonyms

 EIF2AK1, PKR, PPP1R83, PRKR

Description

 Eukaryotic translation initiation factor 2-alpha kinase 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 2

Cytoband

 p22.2

Chromosome location (bp)

 37099210 - 37157065

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000055332 (version 83.38)

Entrez gene

 5610

UniProt

 P19525 (UniProt - Evidence at protein level)

neXtProt

 NX_P19525

Antibodypedia

 EIF2AK2 antibodies

PROTEIN BROWSER
EIF2AK2-001
EIF2AK2-002
EIF2AK2-003
EIF2AK2-004
EIF2AK2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EIF2AK2-001
ENSP00000233057
ENST00000233057
P19525 [Direct mapping]
Interferon-induced, double-stranded RNA-activated protein kinase
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000186 [activation of MAPKK activity]
GO:0001819 [positive regulation of cytokine production]
GO:0003725 [double-stranded RNA binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004694 [eukaryotic translation initiation factor 2alpha kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006351 [transcription, DNA-templated]
GO:0006412 [translation]
GO:0006468 [protein phosphorylation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0009612 [response to mechanical stimulus]
GO:0009615 [response to virus]
GO:0009636 [response to toxic substance]
GO:0010033 [response to organic substance]
GO:0010998 [regulation of translational initiation by eIF2 alpha phosphorylation]
GO:0016020 [membrane]
GO:0017148 [negative regulation of translation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0030683 [evasion or tolerance by virus of host immune response]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032496 [response to lipopolysaccharide]
GO:0032722 [positive regulation of chemokine production]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0033197 [response to vitamin E]
GO:0033689 [negative regulation of osteoblast proliferation]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0035455 [response to interferon-alpha]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043330 [response to exogenous dsRNA]
GO:0044822 [poly(A) RNA binding]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051607 [defense response to virus]
GO:1900225 [regulation of NLRP3 inflammasome complex assembly]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1901532 [regulation of hematopoietic progenitor cell differentiation]
GO:1902033 [regulation of hematopoietic stem cell proliferation]
GO:1902036 [regulation of hematopoietic stem cell differentiation]
Show all
 551 aa
62.1 kDa 		No 0
EIF2AK2-002
ENSP00000385014
ENST00000405334
P19525 [Direct mapping]
Interferon-induced, double-stranded RNA-activated protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000186 [activation of MAPKK activity]
GO:0001819 [positive regulation of cytokine production]
GO:0003725 [double-stranded RNA binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004694 [eukaryotic translation initiation factor 2alpha kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0009615 [response to virus]
GO:0010998 [regulation of translational initiation by eIF2 alpha phosphorylation]
GO:0016020 [membrane]
GO:0017148 [negative regulation of translation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0030683 [evasion or tolerance by virus of host immune response]
GO:0032722 [positive regulation of chemokine production]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0033689 [negative regulation of osteoblast proliferation]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0035455 [response to interferon-alpha]
GO:0044822 [poly(A) RNA binding]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051607 [defense response to virus]
GO:1900225 [regulation of NLRP3 inflammasome complex assembly]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1901532 [regulation of hematopoietic progenitor cell differentiation]
GO:1902033 [regulation of hematopoietic stem cell proliferation]
GO:1902036 [regulation of hematopoietic stem cell differentiation]
Show all
 510 aa
57.4 kDa 		No 0
EIF2AK2-003
ENSP00000374663
ENST00000390013
F8WBH4 [Direct mapping]
Interferon-induced, double-stranded RNA-activated protein kinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 102 aa
11.3 kDa 		No 0
EIF2AK2-004
ENSP00000393921
ENST00000411537
C9JZT2 [Direct mapping]
Interferon-induced, double-stranded RNA-activated protein kinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 141 aa
15.7 kDa 		No 0
EIF2AK2-201
ENSP00000378559
ENST00000395127
P19525 [Direct mapping]
Interferon-induced, double-stranded RNA-activated protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000186 [activation of MAPKK activity]
GO:0001819 [positive regulation of cytokine production]
GO:0003725 [double-stranded RNA binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004694 [eukaryotic translation initiation factor 2alpha kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0009615 [response to virus]
GO:0010998 [regulation of translational initiation by eIF2 alpha phosphorylation]
GO:0016020 [membrane]
GO:0017148 [negative regulation of translation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0030683 [evasion or tolerance by virus of host immune response]
GO:0032722 [positive regulation of chemokine production]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0033689 [negative regulation of osteoblast proliferation]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0035455 [response to interferon-alpha]
GO:0044822 [poly(A) RNA binding]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051607 [defense response to virus]
GO:1900225 [regulation of NLRP3 inflammasome complex assembly]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1901532 [regulation of hematopoietic progenitor cell differentiation]
GO:1902033 [regulation of hematopoietic stem cell proliferation]
GO:1902036 [regulation of hematopoietic stem cell differentiation]
Show all
 551 aa
62.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.