Expression of USP36 in cancer - Summary - The Human Protein Atlas

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USP36

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	USP36
Gene description	Ubiquitin specific peptidase 36
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA012082
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA012082

GENE INFORMATION
Gene name	USP36 (HGNC Symbol)
Synonyms	FLJ12851, KIAA1453
Description	Ubiquitin specific peptidase 36 (HGNC Symbol)
Entrez gene summary	Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP36 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jan 2009]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	78787381 - 78841441
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000055483 (version 83.38)
Entrez gene	57602
UniProt	Q9P275 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P275
Antibodypedia	USP36 antibodies

PROTEIN BROWSER

USP36-002	USP36-003	USP36-004	USP36-010	USP36-011	USP36-012	USP36-014	USP36-015	USP36-018	USP36-021	USP36-029	USP36-201	USP36-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
USP36-002 ENSP00000467682 ENST00000590546	Q8IXW9 [Direct mapping] USP36 protein; Ubiquitin carboxyl-terminal hydrolase 36 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	285 aa 31.8 kDa	No	0
USP36-003 ENSP00000441214 ENST00000542802	Q9P275 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 36 A0A024R8V6 [Target identity:100%; Query identity:100%] Ubiquitin carboxyl-terminal hydrolase Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0044822 [poly(A) RNA binding] GO:0061136 [regulation of proteasomal protein catabolic process] GO:1903146 [regulation of mitophagy] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	1123 aa 122.9 kDa	No	0
USP36-004 ENSP00000465698 ENST00000592231	K7EKN3 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 36 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	69 aa 8.3 kDa	No	0
USP36-010 ENSP00000466212 ENST00000592275	K7ELT3 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 36 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	80 aa 8.7 kDa	No	0
USP36-011 ENSP00000465183 ENST00000588365	K7EJI3 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 36 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	53 aa 5.8 kDa	No	0
USP36-012 ENSP00000467520 ENST00000586531	K7EPT1 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 36 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	179 aa 19.8 kDa	No	0
USP36-014 ENSP00000468194 ENST00000587783	K7ERC1 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 36 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	67 aa 7.4 kDa	No	0
USP36-015 ENSP00000467951 ENST00000586896	K7EQS0 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 36 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	159 aa 17.6 kDa	No	0
USP36-018 ENSP00000466187 ENST00000589424	K7ELR5 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 36 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	234 aa 26.1 kDa	No	0
USP36-021 ENSP00000466567 ENST00000586066	K7EMM6 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 36 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	259 aa 29 kDa	No	0
USP36-029 ENSP00000464746 ENST00000588130	K7EIH0 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 36 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	101 aa 11.9 kDa	No	0
USP36-201 ENSP00000310590 ENST00000312010	Q9P275 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 36 A0A024R8V6 [Target identity:100%; Query identity:100%] Ubiquitin carboxyl-terminal hydrolase Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0044822 [poly(A) RNA binding] GO:0061136 [regulation of proteasomal protein catabolic process] GO:1903146 [regulation of mitophagy] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	1123 aa 122.9 kDa	No	0
USP36-202 ENSP00000401119 ENST00000449938	E9PEW0 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	548 aa 60.3 kDa	No	0

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