Expression of ITIH1 in cancer - Summary

GENERAL INFORMATION
Gene name	ITIH1
Gene description	Inter-alpha-trypsin inhibitor heavy chain 1
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enhanced (Hep G2, HL-60)
HPA (normal tissue):	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct positivity in extracellular material and cytoplasmic expression in adipocytes, Purkinje cells, endothelial cells and trophoblastic cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 2 antibodies. HPA041639 , HPA042049
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA041639	HPA042049

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Malignant cells showed weak to moderate cytoplasmic staining. A few cases of hepatocellular carcinoma and duct carcinoma of breast exhibited strong positivity. Several cases of malignant gliomas and lymphomas were weakly stained or negative.

GENE INFORMATION
Gene name	ITIH1 (HGNC Symbol)
Synonyms	H1P, IATIH, ITIH
Description	Inter-alpha-trypsin inhibitor heavy chain 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the inter-alpha-trypsin inhibitor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the heavy chain of the inter-alpha-trypsin inhibitor complex, which is secreted by hepatocytes into the blood. The heavy chain also interacts with hyaluronan, and this interaction may play a role in ovulation and fertilization, and has been implicated in multiple inflammatory diseases. This gene is present in a gene cluster on chromosome 3. [provided by RefSeq, Nov 2015]
Chromosome	3
Cytoband	p21.1
Chromosome location (bp)	52777592 - 52792068
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000055957 (version 83.38)
Entrez gene	3697
UniProt	P19827 (UniProt - Evidence at protein level)
neXtProt	NX_P19827
Antibodypedia	ITIH1 antibodies

PROTEIN BROWSER

ITIH1-001	ITIH1-002	ITIH1-003	ITIH1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ITIH1-001 ENSP00000273283 ENST00000273283	P19827 [Direct mapping] Inter-alpha-trypsin inhibitor heavy chain H1 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0010951 [negative regulation of endopeptidase activity] GO:0030212 [hyaluronan metabolic process] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	911 aa 101.4 kDa	Yes	0
ITIH1-002 ENSP00000395836 ENST00000428133	H7C0N0 [Direct mapping] Inter-alpha-trypsin inhibitor heavy chain H1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0030212 [hyaluronan metabolic process] Show all	464 aa 51.9 kDa	No	0
ITIH1-003 ENSP00000384589 ENST00000405128	B5MCP1 [Direct mapping] Inter-alpha-trypsin inhibitor heavy chain H1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0030212 [hyaluronan metabolic process] Show all	277 aa 30.5 kDa	No	0
ITIH1-201 ENSP00000443847 ENST00000537050	P19827 [Direct mapping] Inter-alpha-trypsin inhibitor heavy chain H1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0010951 [negative regulation of endopeptidase activity] GO:0030212 [hyaluronan metabolic process] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	623 aa 69.5 kDa	No	0