Tissue expression of ITIH1 - Summary - The Human Protein Atlas

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ITIH1

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ITIH1
Gene description	Inter-alpha-trypsin inhibitor heavy chain 1
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (liver)
GTEx:	Tissue enriched (liver)
FANTOM5:	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression

Distinct positivity in extracellular material and cytoplasmic expression in adipocytes, Purkinje cells, endothelial cells and trophoblastic cells.

DATA RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 2 antibodies. HPA041639 , HPA042049
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

Small intestine

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)

GENE INFORMATION
Gene name	ITIH1 (HGNC Symbol)
Synonyms	H1P, IATIH, ITIH
Description	Inter-alpha-trypsin inhibitor heavy chain 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the inter-alpha-trypsin inhibitor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the heavy chain of the inter-alpha-trypsin inhibitor complex, which is secreted by hepatocytes into the blood. The heavy chain also interacts with hyaluronan, and this interaction may play a role in ovulation and fertilization, and has been implicated in multiple inflammatory diseases. This gene is present in a gene cluster on chromosome 3. [provided by RefSeq, Nov 2015]
Chromosome	3
Cytoband	p21.1
Chromosome location (bp)	52777592 - 52792068
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000055957 (version 83.38)
Entrez gene	3697
UniProt	P19827 (UniProt - Evidence at protein level)
neXtProt	NX_P19827
Antibodypedia	ITIH1 antibodies

PROTEIN BROWSER

ITIH1-001	ITIH1-002	ITIH1-003	ITIH1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ITIH1-001 ENSP00000273283 ENST00000273283	P19827 [Direct mapping] Inter-alpha-trypsin inhibitor heavy chain H1 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0010951 [negative regulation of endopeptidase activity] GO:0030212 [hyaluronan metabolic process] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	911 aa 101.4 kDa	Yes	0
ITIH1-002 ENSP00000395836 ENST00000428133	H7C0N0 [Direct mapping] Inter-alpha-trypsin inhibitor heavy chain H1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0030212 [hyaluronan metabolic process] Show all	464 aa 51.9 kDa	No	0
ITIH1-003 ENSP00000384589 ENST00000405128	B5MCP1 [Direct mapping] Inter-alpha-trypsin inhibitor heavy chain H1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0030212 [hyaluronan metabolic process] Show all	277 aa 30.5 kDa	No	0
ITIH1-201 ENSP00000443847 ENST00000537050	P19827 [Direct mapping] Inter-alpha-trypsin inhibitor heavy chain H1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0010951 [negative regulation of endopeptidase activity] GO:0030212 [hyaluronan metabolic process] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	623 aa 69.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.