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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PKP2
  • TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

PKP2

Gene description

Plakophilin 2

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (CACO-2)
HPA (normal tissue):Tissue enhanced (fallopian tube, heart muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, intercalated discs in heart is highly expressed.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA014314
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in lung cancer (unfavourable) and colorectal cancer (favourable).
Lung cancer p<0.001
Colorectal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA014314

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignancies displayed weak cytoplasmic and membranous staining or were negative. Malignant melanoma colorectal, ovarian, testis and endometrial cancers showed moderate positivity in most cases.

GENE INFORMATION

Gene name

PKP2

Synonyms

Description

Plakophilin 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

p11.21

Chromosome location (bp)

32790745 - 32896840

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000057294 (version 83.38)

Entrez gene

5318

UniProt

Q99959 (UniProt - Evidence at protein level)

neXtProt

NX_Q99959

Antibodypedia

PKP2 antibodies

PROTEIN BROWSER

PKP2-001
PKP2-002
PKP2-003
PKP2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PKP2-001
ENSP00000342800
ENST00000340811
Q99959 [Direct mapping]
Plakophilin-2
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002159 [desmosome assembly]
GO:0003674 [molecular_function]
GO:0005080 [protein kinase C binding]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005882 [intermediate filament]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0007507 [heart development]
GO:0008285 [negative regulation of cell proliferation]
GO:0010765 [positive regulation of sodium ion transport]
GO:0014704 [intercalated disc]
GO:0016021 [integral component of membrane]
GO:0016264 [gap junction assembly]
GO:0016337 [single organismal cell-cell adhesion]
GO:0017080 [sodium channel regulator activity]
GO:0019215 [intermediate filament binding]
GO:0030054 [cell junction]
GO:0030057 [desmosome]
GO:0030336 [negative regulation of cell migration]
GO:0032947 [protein complex scaffold]
GO:0034334 [adherens junction maintenance]
GO:0044325 [ion channel binding]
GO:0045110 [intermediate filament bundle assembly]
GO:0045294 [alpha-catenin binding]
GO:0048496 [maintenance of organ identity]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0055088 [lipid homeostasis]
GO:0086001 [cardiac muscle cell action potential]
GO:0086002 [cardiac muscle cell action potential involved in contraction]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:0086019 [cell-cell signaling involved in cardiac conduction]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
GO:0086073 [bundle of His cell-Purkinje myocyte adhesion involved in cell communication]
GO:0086083 [cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
GO:2000810 [regulation of bicellular tight junction assembly]
Show all
837 aa
92.8 kDa
No 0
PKP2-002
ENSP00000070846
ENST00000070846
Q99959 [Direct mapping]
Plakophilin-2
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002159 [desmosome assembly]
GO:0003674 [molecular_function]
GO:0005080 [protein kinase C binding]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005882 [intermediate filament]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0007507 [heart development]
GO:0008285 [negative regulation of cell proliferation]
GO:0010765 [positive regulation of sodium ion transport]
GO:0014704 [intercalated disc]
GO:0016021 [integral component of membrane]
GO:0016264 [gap junction assembly]
GO:0016337 [single organismal cell-cell adhesion]
GO:0017080 [sodium channel regulator activity]
GO:0019215 [intermediate filament binding]
GO:0030054 [cell junction]
GO:0030057 [desmosome]
GO:0030336 [negative regulation of cell migration]
GO:0032947 [protein complex scaffold]
GO:0034334 [adherens junction maintenance]
GO:0044325 [ion channel binding]
GO:0045110 [intermediate filament bundle assembly]
GO:0045294 [alpha-catenin binding]
GO:0048496 [maintenance of organ identity]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0055088 [lipid homeostasis]
GO:0086001 [cardiac muscle cell action potential]
GO:0086002 [cardiac muscle cell action potential involved in contraction]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:0086019 [cell-cell signaling involved in cardiac conduction]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
GO:0086073 [bundle of His cell-Purkinje myocyte adhesion involved in cell communication]
GO:0086083 [cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
GO:2000810 [regulation of bicellular tight junction assembly]
Show all
881 aa
97.4 kDa
No 0
PKP2-003
ENSP00000481383
ENST00000546741
A0A087WXY2 [Direct mapping]
Plakophilin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
36 aa
3.7 kDa
No 0
PKP2-201
ENSP00000478295
ENST00000613243
B8QGS9 [Direct mapping]
Plakophilin-2; Truncated plakophilin-2
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0016337 [single organismal cell-cell adhesion]
Show all
824 aa
91.2 kDa
No 0

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