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Gene name

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Reliability

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Cancer

Specificity

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Detectable

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Detectable

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Detectable

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PKP2
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

PKP2

Gene description

Plakophilin 2

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (fallopian tube, heart muscle)
GTEx:Tissue enhanced (heart muscle)
FANTOM5:Tissue enhanced (heart muscle)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues, intercalated discs in heart is highly expressed.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA014314
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
N/A
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (fallopian tube, heart muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle)

GENE INFORMATION

Gene name

PKP2

Synonyms

Description

Plakophilin 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

p11.21

Chromosome location (bp)

32790745 - 32896840

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000057294 (version 83.38)

Entrez gene

5318

UniProt

Q99959 (UniProt - Evidence at protein level)

neXtProt

NX_Q99959

Antibodypedia

PKP2 antibodies

PROTEIN BROWSER

PKP2-001
PKP2-002
PKP2-003
PKP2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PKP2-001
ENSP00000342800
ENST00000340811
Q99959 [Direct mapping]
Plakophilin-2
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002159 [desmosome assembly]
GO:0003674 [molecular_function]
GO:0005080 [protein kinase C binding]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005882 [intermediate filament]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0007507 [heart development]
GO:0008285 [negative regulation of cell proliferation]
GO:0010765 [positive regulation of sodium ion transport]
GO:0014704 [intercalated disc]
GO:0016021 [integral component of membrane]
GO:0016264 [gap junction assembly]
GO:0016337 [single organismal cell-cell adhesion]
GO:0017080 [sodium channel regulator activity]
GO:0019215 [intermediate filament binding]
GO:0030054 [cell junction]
GO:0030057 [desmosome]
GO:0030336 [negative regulation of cell migration]
GO:0032947 [protein complex scaffold]
GO:0034334 [adherens junction maintenance]
GO:0044325 [ion channel binding]
GO:0045110 [intermediate filament bundle assembly]
GO:0045294 [alpha-catenin binding]
GO:0048496 [maintenance of organ identity]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0055088 [lipid homeostasis]
GO:0086001 [cardiac muscle cell action potential]
GO:0086002 [cardiac muscle cell action potential involved in contraction]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:0086019 [cell-cell signaling involved in cardiac conduction]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
GO:0086073 [bundle of His cell-Purkinje myocyte adhesion involved in cell communication]
GO:0086083 [cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
GO:2000810 [regulation of bicellular tight junction assembly]
Show all
837 aa
92.8 kDa
No 0
PKP2-002
ENSP00000070846
ENST00000070846
Q99959 [Direct mapping]
Plakophilin-2
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002159 [desmosome assembly]
GO:0003674 [molecular_function]
GO:0005080 [protein kinase C binding]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005882 [intermediate filament]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0007507 [heart development]
GO:0008285 [negative regulation of cell proliferation]
GO:0010765 [positive regulation of sodium ion transport]
GO:0014704 [intercalated disc]
GO:0016021 [integral component of membrane]
GO:0016264 [gap junction assembly]
GO:0016337 [single organismal cell-cell adhesion]
GO:0017080 [sodium channel regulator activity]
GO:0019215 [intermediate filament binding]
GO:0030054 [cell junction]
GO:0030057 [desmosome]
GO:0030336 [negative regulation of cell migration]
GO:0032947 [protein complex scaffold]
GO:0034334 [adherens junction maintenance]
GO:0044325 [ion channel binding]
GO:0045110 [intermediate filament bundle assembly]
GO:0045294 [alpha-catenin binding]
GO:0048496 [maintenance of organ identity]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0055088 [lipid homeostasis]
GO:0086001 [cardiac muscle cell action potential]
GO:0086002 [cardiac muscle cell action potential involved in contraction]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:0086019 [cell-cell signaling involved in cardiac conduction]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
GO:0086073 [bundle of His cell-Purkinje myocyte adhesion involved in cell communication]
GO:0086083 [cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
GO:2000810 [regulation of bicellular tight junction assembly]
Show all
881 aa
97.4 kDa
No 0
PKP2-003
ENSP00000481383
ENST00000546741
A0A087WXY2 [Direct mapping]
Plakophilin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
36 aa
3.7 kDa
No 0
PKP2-201
ENSP00000478295
ENST00000613243
B8QGS9 [Direct mapping]
Plakophilin-2; Truncated plakophilin-2
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0016337 [single organismal cell-cell adhesion]
Show all
824 aa
91.2 kDa
No 0

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