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LAMC2

GENERAL INFORMATION

Gene name

 LAMC2

Gene description

 Laminin, gamma 2

Protein class

 Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (head and neck cancer)
HPA (cell line):Group enriched (A-431, CAPAN-2, EFO-21, HaCaT, hTCEpi, RPTEC TERT1, RT4)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct xpression in basement membranes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Approved based on 3 antibodies.
HPA024638 , CAB004257 , CAB078165
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (unfavourable) and pancreatic cancer (unfavourable).
Lung cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Skin cancer

STAINING SUMMARY
HPA024638
CAB004257
CAB078165

GENE INFORMATION

Gene name

 LAMC2 (HGNC Symbol)

Synonyms

 BM600-100kDa, EBR2, EBR2A, kalinin-105kDa, LAMB2T, LAMNB2, nicein-100kDa

Description

 Laminin, gamma 2 (HGNC Symbol)

Entrez gene summary

 Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature. [provided by RefSeq, Aug 2011]

Chromosome

 1

Cytoband

 q25.3

Chromosome location (bp)

 183186238 - 183244900

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000058085 (version 83.38)

Entrez gene

 3918

UniProt

 Q13753 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13753

Antibodypedia

 LAMC2 antibodies

PROTEIN BROWSER
LAMC2-001
LAMC2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LAMC2-001
ENSP00000264144
ENST00000264144
Q13753 [Direct mapping]
Laminin subunit gamma-2
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005604 [basement membrane]
GO:0005607 [laminin-2 complex]
GO:0005610 [laminin-5 complex]
GO:0005615 [extracellular space]
GO:0005938 [cell cortex]
GO:0007155 [cell adhesion]
GO:0008201 [heparin binding]
GO:0008544 [epidermis development]
GO:0016020 [membrane]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0031581 [hemidesmosome assembly]
GO:0034329 [cell junction assembly]
GO:0048471 [perinuclear region of cytoplasm]
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 1193 aa
131 kDa 		Yes 0
LAMC2-003
ENSP00000432063
ENST00000493293
Q13753 [Direct mapping]
Laminin subunit gamma-2
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007155 [cell adhesion]
GO:0008544 [epidermis development]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0031581 [hemidesmosome assembly]
GO:0034329 [cell junction assembly]
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 1111 aa
121.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.