Expression of SLC2A3 in cancer - Summary

GENERAL INFORMATION
Gene name	SLC2A3
Gene description	Solute carrier family 2 (facilitated glucose transporter), member 3
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (testis cancer)
HPA (cell line):	Group enriched (BEWO, CACO-2, NTERA-2)
HPA (normal tissue):	Tissue enhanced (bone marrow)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression mainly in testis, hematopoietic and lymphoid tissue.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA006539 , CAB002763
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), stomach cancer (unfavourable) and colorectal cancer (unfavourable).
Renal cancer p<0.001 Stomach cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA006539	CAB002763

GENE INFORMATION
Gene name	SLC2A3 (HGNC Symbol)
Synonyms	GLUT3
Description	Solute carrier family 2 (facilitated glucose transporter), member 3 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	7919230 - 7936275
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000059804 (version 83.38)
Entrez gene	6515
UniProt	P11169 (UniProt - Evidence at protein level)
neXtProt	NX_P11169
Antibodypedia	SLC2A3 antibodies

PROTEIN BROWSER

SLC2A3-001	SLC2A3-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC2A3-001 ENSP00000075120 ENST00000075120	P11169 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 3 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005355 [glucose transmembrane transporter activity] GO:0005536 [glucose binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0008645 [hexose transport] GO:0015758 [glucose transport] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019852 [L-ascorbic acid metabolic process] GO:0022857 [transmembrane transporter activity] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0044281 [small molecule metabolic process] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:1904659 [glucose transmembrane transport] Show all	496 aa 53.9 kDa	No	>9
SLC2A3-010 ENSP00000440750 ENST00000544291	F5GYR5 [Direct mapping] Solute carrier family 2, facilitated glucose transporter member 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005351 [sugar:proton symporter activity] GO:0005887 [integral component of plasma membrane] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0022857 [transmembrane transporter activity] GO:0035428 [hexose transmembrane transport] GO:0046323 [glucose import] GO:0055085 [transmembrane transport] Show all	142 aa 15 kDa	No	4