Cell atlas - STYK1 - The Human Protein Atlas

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STYK1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus
	Plasma membrane

Human cell
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	STYK1
Gene description	Serine/threonine/tyrosine kinase 1
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the nucleus.
RNA cell category	Cell line enhanced (CAPAN-2, HUVEC TERT2, TIME)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)
Additional location	In addition localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA040468
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CAPAN-2, HUVEC TERT2, TIME) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the nucleus.

Main location

Plasma membrane (approved)

Additional location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA040468	BJ	Plasma membrane
	HPA040468	RT4	Nucleus
	HPA040468	RT4	Plasma membrane
	HPA040468	U-2 OS	No staining

GENE INFORMATION
Gene name	STYK1 (HGNC Symbol)
Synonyms	DKFZp761P1010, NOK, SuRTK106
Description	Serine/threonine/tyrosine kinase 1 (HGNC Symbol)
Entrez gene summary	Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]
Chromosome	12
Cytoband	p13.2
Chromosome location (bp)	10618939 - 10674318
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000060140 (version 83.38)
Entrez gene	55359
UniProt	Q6J9G0 (UniProt - Evidence at protein level)
neXtProt	NX_Q6J9G0
Antibodypedia	STYK1 antibodies

PROTEIN BROWSER

STYK1-001	STYK1-002	STYK1-003	STYK1-004	STYK1-005	STYK1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STYK1-001 ENSP00000075503 ENST00000075503	Q6J9G0 [Direct mapping] Tyrosine-protein kinase STYK1 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004672 [protein kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0045087 [innate immune response] Show all	422 aa 47.6 kDa	No	1
STYK1-002 ENSP00000446241 ENST00000542562	F5H2I9 [Direct mapping] Tyrosine-protein kinase STYK1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0045087 [innate immune response] Show all	87 aa 9.7 kDa	No	1
STYK1-003 ENSP00000444488 ENST00000535345	F5GZF6 [Direct mapping] Tyrosine-protein kinase STYK1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0045087 [innate immune response] Show all	65 aa 7.5 kDa	No	1
STYK1-004 ENSP00000444942 ENST00000541561	F5H4G3 [Direct mapping] Tyrosine-protein kinase STYK1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0030154 [cell differentiation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0045087 [innate immune response] Show all	41 aa 4.7 kDa	No	1
STYK1-005 ENSP00000445391 ENST00000538867	F5H366 [Direct mapping] Tyrosine-protein kinase STYK1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0045087 [innate immune response] Show all	83 aa 9.3 kDa	No	1
STYK1-006 ENSP00000443760 ENST00000542924	H0YGL5 [Direct mapping] Tyrosine-protein kinase STYK1 Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0030154 [cell differentiation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0045087 [innate immune response] Show all	83 aa 9.5 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.