Expression of STYK1 in cancer - Summary - The Human Protein Atlas

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STYK1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	STYK1
Gene description	Serine/threonine/tyrosine kinase 1
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (CAPAN-2, HUVEC TERT2, TIME)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA048569
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA048569

GENE INFORMATION
Gene name	STYK1 (HGNC Symbol)
Synonyms	DKFZp761P1010, NOK, SuRTK106
Description	Serine/threonine/tyrosine kinase 1 (HGNC Symbol)
Entrez gene summary	Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]
Chromosome	12
Cytoband	p13.2
Chromosome location (bp)	10618939 - 10674318
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000060140 (version 83.38)
Entrez gene	55359
UniProt	Q6J9G0 (UniProt - Evidence at protein level)
neXtProt	NX_Q6J9G0
Antibodypedia	STYK1 antibodies

PROTEIN BROWSER

STYK1-001	STYK1-002	STYK1-003	STYK1-004	STYK1-005	STYK1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STYK1-001 ENSP00000075503 ENST00000075503	Q6J9G0 [Direct mapping] Tyrosine-protein kinase STYK1 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004672 [protein kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0045087 [innate immune response] Show all	422 aa 47.6 kDa	No	1
STYK1-002 ENSP00000446241 ENST00000542562	F5H2I9 [Direct mapping] Tyrosine-protein kinase STYK1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0045087 [innate immune response] Show all	87 aa 9.7 kDa	No	1
STYK1-003 ENSP00000444488 ENST00000535345	F5GZF6 [Direct mapping] Tyrosine-protein kinase STYK1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0045087 [innate immune response] Show all	65 aa 7.5 kDa	No	1
STYK1-004 ENSP00000444942 ENST00000541561	F5H4G3 [Direct mapping] Tyrosine-protein kinase STYK1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0030154 [cell differentiation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0045087 [innate immune response] Show all	41 aa 4.7 kDa	No	1
STYK1-005 ENSP00000445391 ENST00000538867	F5H366 [Direct mapping] Tyrosine-protein kinase STYK1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0045087 [innate immune response] Show all	83 aa 9.3 kDa	No	1
STYK1-006 ENSP00000443760 ENST00000542924	H0YGL5 [Direct mapping] Tyrosine-protein kinase STYK1 Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0030154 [cell differentiation] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0045087 [innate immune response] Show all	83 aa 9.5 kDa	No	0

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