Expression of MPC1 in cancer - Summary - The Human Protein Atlas

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MPC1

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MPC1
Gene description	Mitochondrial pyruvate carrier 1
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA045119
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), lung cancer (favourable) and cervical cancer (favourable).
Renal cancer p<0.001 Lung cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045119

GENE INFORMATION
Gene name	MPC1 (HGNC Symbol)
Synonyms	BRP44L, CGI-129, dJ68L15.3
Description	Mitochondrial pyruvate carrier 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is part of an MPC1/MPC2 heterodimer that is responsible for transporting pyruvate into mitochondria. The encoded protein is found in the inner mitochondrial membrane. Defects in this gene are a cause of mitochondrial pyruvate carrier deficiency. Several transcript variants, some protein coding and one non-protein coding, have been found for this gene. [provided by RefSeq, Aug 2012]
Chromosome	6
Cytoband	q27
Chromosome location (bp)	166364919 - 166383013
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000060762 (version 83.38)
Entrez gene	51660
UniProt	Q9Y5U8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5U8
Antibodypedia	MPC1 antibodies

PROTEIN BROWSER

MPC1-001	MPC1-201	MPC1-202	MPC1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MPC1-001 ENSP00000354223 ENST00000360961	Q9Y5U8 [Direct mapping] Mitochondrial pyruvate carrier 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006090 [pyruvate metabolic process] GO:0006850 [mitochondrial pyruvate transport] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0050833 [pyruvate transmembrane transporter activity] GO:1902361 [mitochondrial pyruvate transmembrane transport] Show all	109 aa 12.3 kDa	No	1
MPC1-201 ENSP00000340784 ENST00000341756	Q5TI65 [Direct mapping] Brain protein 44-like, isoform CRA_a; Mitochondrial pyruvate carrier 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0006850 [mitochondrial pyruvate transport] Show all	66 aa 7.5 kDa	No	0
MPC1-202 ENSP00000479789 ENST00000621630	A0A087WVZ0 [Direct mapping] Mitochondrial pyruvate carrier 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0006850 [mitochondrial pyruvate transport] Show all	109 aa 12.4 kDa	No	1
MPC1-203 ENSP00000477853 ENST00000621685	Q5TI65 [Direct mapping] Brain protein 44-like, isoform CRA_a; Mitochondrial pyruvate carrier 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0006850 [mitochondrial pyruvate transport] Show all	66 aa 7.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.