Tissue expression of MPC1 - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MPC1

premium

TISSUE

premium

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MPC1
Gene description	Mitochondrial pyruvate carrier 1
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression with a granular pattern.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA045119
	SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	MPC1 (HGNC Symbol)
Synonyms	BRP44L, CGI-129, dJ68L15.3
Description	Mitochondrial pyruvate carrier 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is part of an MPC1/MPC2 heterodimer that is responsible for transporting pyruvate into mitochondria. The encoded protein is found in the inner mitochondrial membrane. Defects in this gene are a cause of mitochondrial pyruvate carrier deficiency. Several transcript variants, some protein coding and one non-protein coding, have been found for this gene. [provided by RefSeq, Aug 2012]
Chromosome	6
Cytoband	q27
Chromosome location (bp)	166364919 - 166383013
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000060762 (version 83.38)
Entrez gene	51660
UniProt	Q9Y5U8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5U8
Antibodypedia	MPC1 antibodies

PROTEIN BROWSER

MPC1-001	MPC1-201	MPC1-202	MPC1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MPC1-001 ENSP00000354223 ENST00000360961	Q9Y5U8 [Direct mapping] Mitochondrial pyruvate carrier 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006090 [pyruvate metabolic process] GO:0006850 [mitochondrial pyruvate transport] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0050833 [pyruvate transmembrane transporter activity] GO:1902361 [mitochondrial pyruvate transmembrane transport] Show all	109 aa 12.3 kDa	No	1
MPC1-201 ENSP00000340784 ENST00000341756	Q5TI65 [Direct mapping] Brain protein 44-like, isoform CRA_a; Mitochondrial pyruvate carrier 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0006850 [mitochondrial pyruvate transport] Show all	66 aa 7.5 kDa	No	0
MPC1-202 ENSP00000479789 ENST00000621630	A0A087WVZ0 [Direct mapping] Mitochondrial pyruvate carrier 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0006850 [mitochondrial pyruvate transport] Show all	109 aa 12.4 kDa	No	1
MPC1-203 ENSP00000477853 ENST00000621685	Q5TI65 [Direct mapping] Brain protein 44-like, isoform CRA_a; Mitochondrial pyruvate carrier 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0006850 [mitochondrial pyruvate transport] Show all	66 aa 7.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.