Cell atlas - CA11 - The Human Protein Atlas

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CA11

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubules
	Vesicles

Human cell
	Microtubules
	Vesicles

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GENERAL INFORMATION
Gene name	CA11
Gene description	Carbonic anhydrase XI
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the microtubules & vesicles.
RNA cell category	Cell line enhanced (AN3-CA, SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved), Microtubules (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA041778
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AN3-CA, SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the microtubules & vesicles.

Main location

Vesicles (approved), Microtubules (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA041778	A-431	Vesicles
	HPA041778	A-431	Microtubules
	HPA041778	U-2 OS	Vesicles
	HPA041778	U-2 OS	Microtubules
	HPA041778	U-251 MG	Vesicles
	HPA041778	U-251 MG	Microtubules

GENE INFORMATION
Gene name	CA11 (HGNC Symbol)
Synonyms	CARP2, CARPX1
Description	Carbonic anhydrase XI (HGNC Symbol)
Entrez gene summary	Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	48637942 - 48646312
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000063180 (version 83.38)
Entrez gene	770
UniProt	O75493 (UniProt - Evidence at protein level)
neXtProt	NX_O75493
Antibodypedia	CA11 antibodies

PROTEIN BROWSER

CA11-001	CA11-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CA11-001 ENSP00000084798 ENST00000084798	O75493 [Direct mapping] Carbonic anhydrase-related protein 11 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005576 [extracellular region] GO:0016323 [basolateral plasma membrane] Show all	328 aa 36.2 kDa	Yes	0
CA11-002 ENSP00000469234 ENST00000596080	M0QXK8 [Direct mapping] Carbonic anhydrase-related protein 11 Show all	Predicted intracellular proteins Show all		113 aa 12.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.