Tissue expression of CA11 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CA11
Gene description	Carbonic anhydrase XI
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex)
GTEx:	Expressed in all
FANTOM5:	Group enriched (brain, caudate, cerebellum, hippocampus)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus)

GENE INFORMATION
Gene name	CA11 (HGNC Symbol)
Synonyms	CARP2, CARPX1
Description	Carbonic anhydrase XI (HGNC Symbol)
Entrez gene summary	Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	48637942 - 48646312
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000063180 (version 83.38)
Entrez gene	770
UniProt	O75493 (UniProt - Evidence at protein level)
neXtProt	NX_O75493
Antibodypedia	CA11 antibodies

PROTEIN BROWSER

CA11-001	CA11-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CA11-001 ENSP00000084798 ENST00000084798	O75493 [Direct mapping] Carbonic anhydrase-related protein 11 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005576 [extracellular region] GO:0016323 [basolateral plasma membrane] Show all	328 aa 36.2 kDa	Yes	0
CA11-002 ENSP00000469234 ENST00000596080	M0QXK8 [Direct mapping] Carbonic anhydrase-related protein 11 Show all	Predicted intracellular proteins Show all		113 aa 12.8 kDa	No	0