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CASP8

GENERAL INFORMATION

Gene name

 CASP8

Gene description

 Caspase 8, apoptosis-related cysteine peptidase

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 15
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic staining of varying intensity in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA001302 , HPA005688 , CAB002047
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), ovarian cancer (favourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Ovarian cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001302
HPA005688
CAB002047

GENE INFORMATION

Gene name

 CASP8 (HGNC Symbol)

Synonyms

 Casp-8, FLICE, MACH, MCH5

Description

 Caspase 8, apoptosis-related cysteine peptidase (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q33.1

Chromosome location (bp)

 201233443 - 201287711

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000064012 (version 83.38)

Entrez gene

 841

UniProt

 Q14790 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14790

Antibodypedia

 CASP8 antibodies

PROTEIN BROWSER
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CASP8-002
CASP8-004
CASP8-006
CASP8-009
CASP8-010
CASP8-012
CASP8-014
CASP8-016
CASP8-017
CASP8-020
CASP8-021
CASP8-023
CASP8-026
CASP8-201
CASP8-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CASP8-002
ENSP00000351273
ENST00000358485
Q14790 [Direct mapping]
Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001841 [neural tube formation]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004175 [endopeptidase activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005123 [death receptor binding]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007507 [heart development]
GO:0008233 [peptidase activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0009409 [response to cold]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0030101 [natural killer cell activation]
GO:0030225 [macrophage differentiation]
GO:0030690 [Noc1p-Noc2p complex]
GO:0031264 [death-inducing signaling complex]
GO:0031265 [CD95 death-inducing signaling complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032025 [response to cobalt ion]
GO:0032355 [response to estradiol]
GO:0032403 [protein complex binding]
GO:0032496 [response to lipopolysaccharide]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034612 [response to tumor necrosis factor]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0035877 [death effector domain binding]
GO:0036462 [TRAIL-activated apoptotic signaling pathway]
GO:0042110 [T cell activation]
GO:0042113 [B cell activation]
GO:0042981 [regulation of apoptotic process]
GO:0043005 [neuron projection]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043234 [protein complex]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045471 [response to ethanol]
GO:0045651 [positive regulation of macrophage differentiation]
GO:0045862 [positive regulation of proteolysis]
GO:0046677 [response to antibiotic]
GO:0046982 [protein heterodimerization activity]
GO:0051291 [protein heterooligomerization]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0060546 [negative regulation of necroptotic process]
GO:0060715 [syncytiotrophoblast cell differentiation involved in labyrinthine layer development]
GO:0070243 [regulation of thymocyte apoptotic process]
GO:0070266 [necroptotic process]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071550 [death-inducing signaling complex assembly]
GO:0097110 [scaffold protein binding]
GO:0097153 [cysteine-type endopeptidase activity involved in apoptotic process]
GO:0097190 [apoptotic signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097194 [execution phase of apoptosis]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097202 [activation of cysteine-type endopeptidase activity]
GO:0097284 [hepatocyte apoptotic process]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:0097342 [ripoptosome]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2001233 [regulation of apoptotic signaling pathway]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 538 aa
61.8 kDa 		No 0
CASP8-004
ENSP00000376087
ENST00000392258
Q14790 [Direct mapping]
Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008233 [peptidase activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0030101 [natural killer cell activation]
GO:0030225 [macrophage differentiation]
GO:0031264 [death-inducing signaling complex]
GO:0031265 [CD95 death-inducing signaling complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034612 [response to tumor necrosis factor]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0035877 [death effector domain binding]
GO:0036462 [TRAIL-activated apoptotic signaling pathway]
GO:0042110 [T cell activation]
GO:0042113 [B cell activation]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045087 [innate immune response]
GO:0045651 [positive regulation of macrophage differentiation]
GO:0045862 [positive regulation of proteolysis]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0060715 [syncytiotrophoblast cell differentiation involved in labyrinthine layer development]
GO:0070266 [necroptotic process]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071550 [death-inducing signaling complex assembly]
GO:0097110 [scaffold protein binding]
GO:0097153 [cysteine-type endopeptidase activity involved in apoptotic process]
GO:0097190 [apoptotic signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097194 [execution phase of apoptosis]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097202 [activation of cysteine-type endopeptidase activity]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:0097342 [ripoptosome]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
Show all
 235 aa
27.5 kDa 		No 0
CASP8-006
ENSP00000264275
ENST00000264275
Q14790 [Direct mapping]
Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008233 [peptidase activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0030101 [natural killer cell activation]
GO:0030225 [macrophage differentiation]
GO:0031264 [death-inducing signaling complex]
GO:0031265 [CD95 death-inducing signaling complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034612 [response to tumor necrosis factor]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0035877 [death effector domain binding]
GO:0036462 [TRAIL-activated apoptotic signaling pathway]
GO:0042110 [T cell activation]
GO:0042113 [B cell activation]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045087 [innate immune response]
GO:0045651 [positive regulation of macrophage differentiation]
GO:0045862 [positive regulation of proteolysis]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0060715 [syncytiotrophoblast cell differentiation involved in labyrinthine layer development]
GO:0070266 [necroptotic process]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071550 [death-inducing signaling complex assembly]
GO:0097110 [scaffold protein binding]
GO:0097153 [cysteine-type endopeptidase activity involved in apoptotic process]
GO:0097190 [apoptotic signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097194 [execution phase of apoptosis]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097202 [activation of cysteine-type endopeptidase activity]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:0097342 [ripoptosome]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
Show all
 496 aa
57.7 kDa 		No 0
CASP8-009
ENSP00000376091
ENST00000392263
Q14790 [Direct mapping]
Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10
A0A024R3Z8 [Target identity:100%; Query identity:100%]
HCG16983, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008233 [peptidase activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0030101 [natural killer cell activation]
GO:0030225 [macrophage differentiation]
GO:0031264 [death-inducing signaling complex]
GO:0031265 [CD95 death-inducing signaling complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034612 [response to tumor necrosis factor]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0035877 [death effector domain binding]
GO:0036462 [TRAIL-activated apoptotic signaling pathway]
GO:0042110 [T cell activation]
GO:0042113 [B cell activation]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045087 [innate immune response]
GO:0045651 [positive regulation of macrophage differentiation]
GO:0045862 [positive regulation of proteolysis]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0060715 [syncytiotrophoblast cell differentiation involved in labyrinthine layer development]
GO:0070266 [necroptotic process]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071550 [death-inducing signaling complex assembly]
GO:0097110 [scaffold protein binding]
GO:0097153 [cysteine-type endopeptidase activity involved in apoptotic process]
GO:0097190 [apoptotic signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097194 [execution phase of apoptosis]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097202 [activation of cysteine-type endopeptidase activity]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:0097342 [ripoptosome]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
Show all
 464 aa
53.8 kDa 		No 0
CASP8-010
ENSP00000388306
ENST00000447616
E7EQ06 [Direct mapping]
Caspase-8
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0042981 [regulation of apoptotic process]
Show all
 209 aa
24.7 kDa 		No 0
CASP8-012
ENSP00000325722
ENST00000323492
Q14790 [Direct mapping]
Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10
A0A024R3Z8 [Target identity:100%; Query identity:100%]
HCG16983, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008233 [peptidase activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0030101 [natural killer cell activation]
GO:0030225 [macrophage differentiation]
GO:0031264 [death-inducing signaling complex]
GO:0031265 [CD95 death-inducing signaling complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034612 [response to tumor necrosis factor]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0035877 [death effector domain binding]
GO:0036462 [TRAIL-activated apoptotic signaling pathway]
GO:0042110 [T cell activation]
GO:0042113 [B cell activation]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045087 [innate immune response]
GO:0045651 [positive regulation of macrophage differentiation]
GO:0045862 [positive regulation of proteolysis]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0060715 [syncytiotrophoblast cell differentiation involved in labyrinthine layer development]
GO:0070266 [necroptotic process]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071550 [death-inducing signaling complex assembly]
GO:0097110 [scaffold protein binding]
GO:0097153 [cysteine-type endopeptidase activity involved in apoptotic process]
GO:0097190 [apoptotic signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097194 [execution phase of apoptosis]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097202 [activation of cysteine-type endopeptidase activity]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:0097342 [ripoptosome]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
Show all
 464 aa
53.8 kDa 		No 0
CASP8-014
ENSP00000412523
ENST00000432109
Q14790 [Direct mapping]
Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008233 [peptidase activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0030101 [natural killer cell activation]
GO:0030225 [macrophage differentiation]
GO:0031264 [death-inducing signaling complex]
GO:0031265 [CD95 death-inducing signaling complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034612 [response to tumor necrosis factor]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0035877 [death effector domain binding]
GO:0036462 [TRAIL-activated apoptotic signaling pathway]
GO:0042110 [T cell activation]
GO:0042113 [B cell activation]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045087 [innate immune response]
GO:0045651 [positive regulation of macrophage differentiation]
GO:0045862 [positive regulation of proteolysis]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0060715 [syncytiotrophoblast cell differentiation involved in labyrinthine layer development]
GO:0070266 [necroptotic process]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071550 [death-inducing signaling complex assembly]
GO:0097110 [scaffold protein binding]
GO:0097153 [cysteine-type endopeptidase activity involved in apoptotic process]
GO:0097190 [apoptotic signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097194 [execution phase of apoptosis]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097202 [activation of cysteine-type endopeptidase activity]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:0097342 [ripoptosome]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
Show all
 479 aa
55.4 kDa 		No 0
CASP8-016
ENSP00000390346
ENST00000424461
H7BZM4 [Direct mapping]
Caspase-8
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0042981 [regulation of apoptotic process]
Show all
 83 aa
9.4 kDa 		No 0
CASP8-017
ENSP00000394434
ENST00000444430
H7C0E2 [Direct mapping]
Caspase-8
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0008234 [cysteine-type peptidase activity]
GO:0042981 [regulation of apoptotic process]
Show all
 258 aa
29.5 kDa 		No 0
CASP8-020
ENSP00000391709
ENST00000450491
C9JB29 [Direct mapping]
Caspase-8
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0006508 [proteolysis]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0042981 [regulation of apoptotic process]
Show all
 149 aa
17.3 kDa 		No 0
CASP8-021
ENSP00000396869
ENST00000440732
E7EVN1 [Direct mapping]
Caspase-8
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0042981 [regulation of apoptotic process]
Show all
 124 aa
14.9 kDa 		No 0
CASP8-023
ENSP00000397528
ENST00000413726
E7ETB7 [Direct mapping]
Caspase-8
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0042981 [regulation of apoptotic process]
Show all
 198 aa
23.5 kDa 		No 0
CASP8-026
ENSP00000390641
ENST00000429881
E7EQ01 [Direct mapping]
Caspase-8
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0042981 [regulation of apoptotic process]
Show all
 116 aa
13.9 kDa 		No 0
CASP8-201
ENSP00000264274
ENST00000264274
Q14790 [Direct mapping]
Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008233 [peptidase activity]
GO:0008234 [cysteine-type peptidase activity]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010939 [regulation of necrotic cell death]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0030101 [natural killer cell activation]
GO:0030225 [macrophage differentiation]
GO:0031264 [death-inducing signaling complex]
GO:0031265 [CD95 death-inducing signaling complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034612 [response to tumor necrosis factor]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0035877 [death effector domain binding]
GO:0036462 [TRAIL-activated apoptotic signaling pathway]
GO:0042110 [T cell activation]
GO:0042113 [B cell activation]
GO:0042981 [regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045087 [innate immune response]
GO:0045651 [positive regulation of macrophage differentiation]
GO:0045862 [positive regulation of proteolysis]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0060715 [syncytiotrophoblast cell differentiation involved in labyrinthine layer development]
GO:0070266 [necroptotic process]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071550 [death-inducing signaling complex assembly]
GO:0097110 [scaffold protein binding]
GO:0097153 [cysteine-type endopeptidase activity involved in apoptotic process]
GO:0097190 [apoptotic signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097194 [execution phase of apoptosis]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097202 [activation of cysteine-type endopeptidase activity]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0097300 [programmed necrotic cell death]
GO:0097342 [ripoptosome]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
Show all
 395 aa
45.9 kDa 		No 0
CASP8-202
ENSP00000376094
ENST00000392266
A0A0A0MS31 [Direct mapping]
Caspase-8
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0006508 [proteolysis]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0042981 [regulation of apoptotic process]
Show all
 278 aa
32.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.