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Selective cytoplasmic expression in peripheral nerves, reticular fibers of germinal centra, myoepthelia and basal cells of surface epithelium and glandular epithelia of seminal vesicle and prostate.
ANTIBODY IHC RELIABILITY
Data reliability description
Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Malignant gliomas displayed strong membranous immunoreactivity in several cases. Remaining tumors were in general negative.
GENE INFORMATION
Gene name
NGFR (HGNC Symbol)
Synonyms
CD271, p75NTR, TNFRSF16
Description
Nerve growth factor receptor (HGNC Symbol)
Entrez gene summary
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]