Cell atlas - FAR2 - The Human Protein Atlas

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FAR2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus
	Nucleoli

Human cell
	Golgi Apparatus
	Nucleoli

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GENERAL INFORMATION
Gene name	FAR2
Gene description	Fatty acyl CoA reductase 2
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the Golgi apparatus. In addition localized to the nucleoli.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (approved)
Additional location	In addition localized to the Nucleoli (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA015884
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the Golgi apparatus. In addition localized to the nucleoli.

Main location

Golgi apparatus (approved)

Additional location

Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA015884	A-431	Nucleoli
	HPA015884	A-431	Golgi apparatus
	HPA015884	U-2 OS	Golgi apparatus
	HPA015884	U-251 MG	Golgi apparatus

GENE INFORMATION
Gene name	FAR2 (HGNC Symbol)
Synonyms	FLJ10462, MLSTD1, SDR10E2
Description	Fatty acyl CoA reductase 2 (HGNC Symbol)
Entrez gene summary	This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012]
Chromosome	12
Cytoband	p11.22
Chromosome location (bp)	29149103 - 29340980
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000064763 (version 83.38)
Entrez gene	55711
UniProt	Q96K12 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96K12
Antibodypedia	FAR2 antibodies

PROTEIN BROWSER

FAR2-001	FAR2-002	FAR2-003	FAR2-004	FAR2-009	FAR2-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAR2-001 ENSP00000443291 ENST00000536681	Q96K12 [Direct mapping] Fatty acyl-CoA reductase 2 A0A024RAW7 [Target identity:100%; Query identity:100%] Male sterility domain containing 1, isoform CRA_a Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0005782 [peroxisomal matrix] GO:0005789 [endoplasmic reticulum membrane] GO:0008611 [ether lipid biosynthetic process] GO:0010025 [wax biosynthetic process] GO:0016021 [integral component of membrane] GO:0035336 [long-chain fatty-acyl-CoA metabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0050062 [long-chain-fatty-acyl-CoA reductase activity] GO:0055114 [oxidation-reduction process] GO:0080019 [fatty-acyl-CoA reductase (alcohol-forming) activity] Show all	515 aa 59.4 kDa	No	3
FAR2-002 ENSP00000182377 ENST00000182377	Q96K12 [Direct mapping] Fatty acyl-CoA reductase 2 A0A024RAW7 [Target identity:100%; Query identity:100%] Male sterility domain containing 1, isoform CRA_a Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0005782 [peroxisomal matrix] GO:0005789 [endoplasmic reticulum membrane] GO:0008611 [ether lipid biosynthetic process] GO:0010025 [wax biosynthetic process] GO:0016021 [integral component of membrane] GO:0035336 [long-chain fatty-acyl-CoA metabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0080019 [fatty-acyl-CoA reductase (alcohol-forming) activity] Show all	515 aa 59.4 kDa	No	3
FAR2-003 ENSP00000449349 ENST00000547116	Q96K12 [Direct mapping] Fatty acyl-CoA reductase 2 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0005782 [peroxisomal matrix] GO:0005789 [endoplasmic reticulum membrane] GO:0008611 [ether lipid biosynthetic process] GO:0010025 [wax biosynthetic process] GO:0016021 [integral component of membrane] GO:0035336 [long-chain fatty-acyl-CoA metabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0080019 [fatty-acyl-CoA reductase (alcohol-forming) activity] Show all	418 aa 48.5 kDa	No	3
FAR2-004 ENSP00000450117 ENST00000551451	F8VPF2 [Direct mapping] Fatty acyl-CoA reductase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005777 [peroxisome] GO:0010025 [wax biosynthetic process] GO:0055114 [oxidation-reduction process] GO:0080019 [fatty-acyl-CoA reductase (alcohol-forming) activity] Show all	44 aa 5 kDa	No	0
FAR2-009 ENSP00000449187 ENST00000551193	H0YIE0 [Direct mapping] Fatty acyl-CoA reductase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005777 [peroxisome] GO:0010025 [wax biosynthetic process] GO:0016021 [integral component of membrane] GO:0055114 [oxidation-reduction process] GO:0080019 [fatty-acyl-CoA reductase (alcohol-forming) activity] Show all	85 aa 10.4 kDa	No	1
FAR2-010 ENSP00000447467 ENST00000547759	H0YHP1 [Direct mapping] Fatty acyl-CoA reductase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005777 [peroxisome] GO:0010025 [wax biosynthetic process] Show all	22 aa 2.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.