Expression of FAR2 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

FAR2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FAR2
Gene description	Fatty acyl CoA reductase 2
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression at varying levels in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA015884
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA015884

GENE INFORMATION
Gene name	FAR2 (HGNC Symbol)
Synonyms	FLJ10462, MLSTD1, SDR10E2
Description	Fatty acyl CoA reductase 2 (HGNC Symbol)
Entrez gene summary	This gene belongs to the short chain dehydrogenase/reductase superfamily. It encodes a reductase enzyme involved in the first step of wax biosynthesis wherein fatty acids are converted to fatty alcohols. The encoded peroxisomal protein utilizes saturated fatty acids of 16 or 18 carbons as preferred substrates. Alternatively spliced transcript variants have been observed for this gene. Related pseudogenes have been identified on chromosomes 2, 14 and 22. [provided by RefSeq, Nov 2012]
Chromosome	12
Cytoband	p11.22
Chromosome location (bp)	29149103 - 29340980
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000064763 (version 83.38)
Entrez gene	55711
UniProt	Q96K12 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96K12
Antibodypedia	FAR2 antibodies

PROTEIN BROWSER

FAR2-001	FAR2-002	FAR2-003	FAR2-004	FAR2-009	FAR2-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAR2-001 ENSP00000443291 ENST00000536681	Q96K12 [Direct mapping] Fatty acyl-CoA reductase 2 A0A024RAW7 [Target identity:100%; Query identity:100%] Male sterility domain containing 1, isoform CRA_a Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0005782 [peroxisomal matrix] GO:0005789 [endoplasmic reticulum membrane] GO:0008611 [ether lipid biosynthetic process] GO:0010025 [wax biosynthetic process] GO:0016021 [integral component of membrane] GO:0035336 [long-chain fatty-acyl-CoA metabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0050062 [long-chain-fatty-acyl-CoA reductase activity] GO:0055114 [oxidation-reduction process] GO:0080019 [fatty-acyl-CoA reductase (alcohol-forming) activity] Show all	515 aa 59.4 kDa	No	3
FAR2-002 ENSP00000182377 ENST00000182377	Q96K12 [Direct mapping] Fatty acyl-CoA reductase 2 A0A024RAW7 [Target identity:100%; Query identity:100%] Male sterility domain containing 1, isoform CRA_a Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0005782 [peroxisomal matrix] GO:0005789 [endoplasmic reticulum membrane] GO:0008611 [ether lipid biosynthetic process] GO:0010025 [wax biosynthetic process] GO:0016021 [integral component of membrane] GO:0035336 [long-chain fatty-acyl-CoA metabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0080019 [fatty-acyl-CoA reductase (alcohol-forming) activity] Show all	515 aa 59.4 kDa	No	3
FAR2-003 ENSP00000449349 ENST00000547116	Q96K12 [Direct mapping] Fatty acyl-CoA reductase 2 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0005782 [peroxisomal matrix] GO:0005789 [endoplasmic reticulum membrane] GO:0008611 [ether lipid biosynthetic process] GO:0010025 [wax biosynthetic process] GO:0016021 [integral component of membrane] GO:0035336 [long-chain fatty-acyl-CoA metabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0080019 [fatty-acyl-CoA reductase (alcohol-forming) activity] Show all	418 aa 48.5 kDa	No	3
FAR2-004 ENSP00000450117 ENST00000551451	F8VPF2 [Direct mapping] Fatty acyl-CoA reductase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005777 [peroxisome] GO:0010025 [wax biosynthetic process] GO:0055114 [oxidation-reduction process] GO:0080019 [fatty-acyl-CoA reductase (alcohol-forming) activity] Show all	44 aa 5 kDa	No	0
FAR2-009 ENSP00000449187 ENST00000551193	H0YIE0 [Direct mapping] Fatty acyl-CoA reductase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005777 [peroxisome] GO:0010025 [wax biosynthetic process] GO:0016021 [integral component of membrane] GO:0055114 [oxidation-reduction process] GO:0080019 [fatty-acyl-CoA reductase (alcohol-forming) activity] Show all	85 aa 10.4 kDa	No	1
FAR2-010 ENSP00000447467 ENST00000547759	H0YHP1 [Direct mapping] Fatty acyl-CoA reductase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005777 [peroxisome] GO:0010025 [wax biosynthetic process] Show all	22 aa 2.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.