Cell atlas - GNAI3 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	GNAI3
Gene description	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the centrosome. In addition localized to the nucleus & nucleoli. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Centrosome (supported)
Additional location	In addition localized to the Nucleus (approved), Nucleoli (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA042141
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the centrosome. In addition localized to the nucleus & nucleoli. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Centrosome (supported)

Additional location

Nucleus (approved), Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA042141	A-431	Centrosome
HPA042141	A549	Nucleus
		Nucleoli
		Centrosome
HPA042141	U-2 OS	No staining

GENE INFORMATION
Gene name	GNAI3 (HGNC Symbol)
Synonyms	87U6
Description	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 (HGNC Symbol)
Entrez gene summary	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012]
Chromosome	1
Cytoband	p13.3
Chromosome location (bp)	109548611 - 109618321
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000065135 (version 83.38)
Entrez gene	2773
UniProt	P08754 (UniProt - Evidence at protein level)
neXtProt	NX_P08754
Antibodypedia	GNAI3 antibodies

PROTEIN BROWSER

GNAI3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GNAI3-001 ENSP00000358867 ENST00000369851	P08754 [Direct mapping] Guanine nucleotide-binding protein G(k) subunit alpha Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005765 [lysosomal membrane] GO:0005794 [Golgi apparatus] GO:0005813 [centrosome] GO:0005834 [heterotrimeric G-protein complex] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006906 [vesicle fusion] GO:0007049 [cell cycle] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0019001 [guanyl nucleotide binding] GO:0019904 [protein domain specific binding] GO:0030168 [platelet activation] GO:0030496 [midbody] GO:0031683 [G-protein beta/gamma-subunit complex binding] GO:0031821 [G-protein coupled serotonin receptor binding] GO:0032794 [GTPase activating protein binding] GO:0042588 [zymogen granule] GO:0045121 [membrane raft] GO:0046872 [metal ion binding] GO:0051301 [cell division] GO:0070062 [extracellular exosome] Show all	354 aa 40.5 kDa	No	0