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GNAI3

GENERAL INFORMATION

Gene name

 GNAI3

Gene description

 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB022099
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), colorectal cancer (favourable), renal cancer (unfavourable) and ovarian cancer (favourable).
Liver cancer p<0.001
Colorectal cancer p<0.001
Renal cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB022099

GENE INFORMATION

Gene name

 GNAI3 (HGNC Symbol)

Synonyms

 87U6

Description

 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 (HGNC Symbol)

Entrez gene summary

 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012]

Chromosome

 1

Cytoband

 p13.3

Chromosome location (bp)

 109548611 - 109618321

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000065135 (version 83.38)

Entrez gene

 2773

UniProt

 P08754 (UniProt - Evidence at protein level)

neXtProt

 NX_P08754

Antibodypedia

 GNAI3 antibodies

PROTEIN BROWSER
GNAI3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNAI3-001
ENSP00000358867
ENST00000369851
P08754 [Direct mapping]
Guanine nucleotide-binding protein G(k) subunit alpha
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006906 [vesicle fusion]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0019904 [protein domain specific binding]
GO:0030168 [platelet activation]
GO:0030496 [midbody]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031821 [G-protein coupled serotonin receptor binding]
GO:0032794 [GTPase activating protein binding]
GO:0042588 [zymogen granule]
GO:0045121 [membrane raft]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
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 354 aa
40.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.