Expression of ERBB3 in cancer - Summary - The Human Protein Atlas

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ERBB3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ERBB3
Gene description	Erb-b2 receptor tyrosine kinase 3
Protein class	Cancer-related genes Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (SK-MEL-30, T-47d, WM-115)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membran expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 2 antibodies. HPA045396 , CAB025331
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045396	CAB025331

GENE INFORMATION
Gene name	ERBB3 (HGNC Symbol)
Synonyms	HER3, LCCS2
Description	Erb-b2 receptor tyrosine kinase 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q13.2
Chromosome location (bp)	56079857 - 56103505
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000065361 (version 83.38)
Entrez gene	2065
UniProt	P21860 (UniProt - Evidence at protein level)
neXtProt	NX_P21860
Antibodypedia	ERBB3 antibodies

PROTEIN BROWSER

ERBB3-001	ERBB3-004	ERBB3-005	ERBB3-006	ERBB3-009	ERBB3-010	ERBB3-011	ERBB3-020	ERBB3-024	ERBB3-025

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ERBB3-001 ENSP00000267101 ENST00000267101	P21860 [Direct mapping] Receptor tyrosine-protein kinase erbB-3 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0003197 [endocardial cushion development] GO:0004672 [protein kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0004716 [receptor signaling protein tyrosine kinase activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007162 [negative regulation of cell adhesion] GO:0007165 [signal transduction] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0007422 [peripheral nervous system development] GO:0007507 [heart development] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009968 [negative regulation of signal transduction] GO:0014037 [Schwann cell differentiation] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0016328 [lateral plasma membrane] GO:0019838 [growth factor binding] GO:0021545 [cranial nerve development] GO:0030296 [protein tyrosine kinase activator activity] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042060 [wound healing] GO:0042127 [regulation of cell proliferation] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043235 [receptor complex] GO:0043524 [negative regulation of neuron apoptotic process] GO:0045087 [innate immune response] GO:0046982 [protein heterodimerization activity] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051048 [negative regulation of secretion] GO:0051402 [neuron apoptotic process] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] Show all	1342 aa 148.1 kDa	Yes	1
ERBB3-004 ENSP00000448729 ENST00000549832	B3KWG5 [Direct mapping] Receptor tyrosine-protein kinase erbB-3; cDNA FLJ43038 fis, clone BRTHA3002955, highly similar to Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0006468 [protein phosphorylation] Show all	462 aa 50.7 kDa	No	0
ERBB3-005 ENSP00000449129 ENST00000553131	F8VW56 [Direct mapping] Receptor tyrosine-protein kinase erbB-3 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	583 aa 64.3 kDa	No	0
ERBB3-006 ENSP00000415753 ENST00000411731	P21860 [Direct mapping] Receptor tyrosine-protein kinase erbB-3 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007162 [negative regulation of cell adhesion] GO:0007165 [signal transduction] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0007422 [peripheral nervous system development] GO:0007507 [heart development] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009968 [negative regulation of signal transduction] GO:0014037 [Schwann cell differentiation] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016323 [basolateral plasma membrane] GO:0019838 [growth factor binding] GO:0021545 [cranial nerve development] GO:0030296 [protein tyrosine kinase activator activity] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042060 [wound healing] GO:0042127 [regulation of cell proliferation] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043235 [receptor complex] GO:0043524 [negative regulation of neuron apoptotic process] GO:0045087 [innate immune response] GO:0046982 [protein heterodimerization activity] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051048 [negative regulation of secretion] GO:0051402 [neuron apoptotic process] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] Show all	183 aa 20.1 kDa	Yes	0
ERBB3-009 ENSP00000448946 ENST00000550070	F8VYK4 [Direct mapping] Receptor tyrosine-protein kinase erbB-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0006468 [protein phosphorylation] GO:0016021 [integral component of membrane] Show all	649 aa 71.6 kDa	No	1
ERBB3-010 ENSP00000448636 ENST00000549282	F8VRL0 [Direct mapping] Receptor tyrosine-protein kinase erbB-3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all		126 aa 14 kDa	Yes	0
ERBB3-011 ENSP00000449138 ENST00000549061	F8VW48 [Direct mapping] Receptor tyrosine-protein kinase erbB-3 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all		116 aa 13.3 kDa	No	0
ERBB3-020 ENSP00000449713 ENST00000549672	F8VX90 [Direct mapping] Receptor tyrosine-protein kinase erbB-3 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all		115 aa 13.2 kDa	No	0
ERBB3-024 ENSP00000408340 ENST00000415288	P21860 [Direct mapping] Receptor tyrosine-protein kinase erbB-3 Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0004672 [protein kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0004716 [receptor signaling protein tyrosine kinase activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007162 [negative regulation of cell adhesion] GO:0007165 [signal transduction] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0007422 [peripheral nervous system development] GO:0007507 [heart development] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009968 [negative regulation of signal transduction] GO:0014037 [Schwann cell differentiation] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0019838 [growth factor binding] GO:0021545 [cranial nerve development] GO:0030296 [protein tyrosine kinase activator activity] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042060 [wound healing] GO:0042127 [regulation of cell proliferation] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043235 [receptor complex] GO:0043524 [negative regulation of neuron apoptotic process] GO:0045087 [innate immune response] GO:0046982 [protein heterodimerization activity] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051048 [negative regulation of secretion] GO:0051402 [neuron apoptotic process] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] Show all	1283 aa 141.8 kDa	No	1
ERBB3-025 ENSP00000482073 ENST00000550828	O75812 [Direct mapping] ErbB-3 R31; Receptor tyrosine-protein kinase erbB-3 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all		81 aa 8.5 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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