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ERBB3

GENERAL INFORMATION

Gene name

 ERBB3

Gene description

 Erb-b2 receptor tyrosine kinase 3

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membran expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA045396 , CAB025331
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 ERBB3 (HGNC Symbol)

Synonyms

 HER3, LCCS2

Description

 Erb-b2 receptor tyrosine kinase 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.2

Chromosome location (bp)

 56079857 - 56103505

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000065361 (version 83.38)

Entrez gene

 2065

UniProt

 P21860 (UniProt - Evidence at protein level)

neXtProt

 NX_P21860

Antibodypedia

 ERBB3 antibodies

PROTEIN BROWSER
ERBB3-001
ERBB3-004
ERBB3-005
ERBB3-006
ERBB3-009
ERBB3-010
ERBB3-011
ERBB3-020
ERBB3-024
ERBB3-025

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ERBB3-001
ENSP00000267101
ENST00000267101
P21860 [Direct mapping]
Receptor tyrosine-protein kinase erbB-3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0003197 [endocardial cushion development]
GO:0004672 [protein kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007162 [negative regulation of cell adhesion]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007422 [peripheral nervous system development]
GO:0007507 [heart development]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0014037 [Schwann cell differentiation]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0019838 [growth factor binding]
GO:0021545 [cranial nerve development]
GO:0030296 [protein tyrosine kinase activator activity]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042060 [wound healing]
GO:0042127 [regulation of cell proliferation]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043235 [receptor complex]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045087 [innate immune response]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051048 [negative regulation of secretion]
GO:0051402 [neuron apoptotic process]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 1342 aa
148.1 kDa 		Yes 1
ERBB3-004
ENSP00000448729
ENST00000549832
B3KWG5 [Direct mapping]
Receptor tyrosine-protein kinase erbB-3; cDNA FLJ43038 fis, clone BRTHA3002955, highly similar to Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1)
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0006468 [protein phosphorylation]
Show all
 462 aa
50.7 kDa 		No 0
ERBB3-005
ENSP00000449129
ENST00000553131
F8VW56 [Direct mapping]
Receptor tyrosine-protein kinase erbB-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 583 aa
64.3 kDa 		No 0
ERBB3-006
ENSP00000415753
ENST00000411731
P21860 [Direct mapping]
Receptor tyrosine-protein kinase erbB-3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007162 [negative regulation of cell adhesion]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007422 [peripheral nervous system development]
GO:0007507 [heart development]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0014037 [Schwann cell differentiation]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016323 [basolateral plasma membrane]
GO:0019838 [growth factor binding]
GO:0021545 [cranial nerve development]
GO:0030296 [protein tyrosine kinase activator activity]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042060 [wound healing]
GO:0042127 [regulation of cell proliferation]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043235 [receptor complex]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045087 [innate immune response]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051048 [negative regulation of secretion]
GO:0051402 [neuron apoptotic process]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 183 aa
20.1 kDa 		Yes 0
ERBB3-009
ENSP00000448946
ENST00000550070
F8VYK4 [Direct mapping]
Receptor tyrosine-protein kinase erbB-3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0006468 [protein phosphorylation]
GO:0016021 [integral component of membrane]
Show all
 649 aa
71.6 kDa 		No 1
ERBB3-010
ENSP00000448636
ENST00000549282
F8VRL0 [Direct mapping]
Receptor tyrosine-protein kinase erbB-3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 126 aa
14 kDa 		Yes 0
ERBB3-011
ENSP00000449138
ENST00000549061
F8VW48 [Direct mapping]
Receptor tyrosine-protein kinase erbB-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 116 aa
13.3 kDa 		No 0
ERBB3-020
ENSP00000449713
ENST00000549672
F8VX90 [Direct mapping]
Receptor tyrosine-protein kinase erbB-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 115 aa
13.2 kDa 		No 0
ERBB3-024
ENSP00000408340
ENST00000415288
P21860 [Direct mapping]
Receptor tyrosine-protein kinase erbB-3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007162 [negative regulation of cell adhesion]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007422 [peripheral nervous system development]
GO:0007507 [heart development]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0014037 [Schwann cell differentiation]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0019838 [growth factor binding]
GO:0021545 [cranial nerve development]
GO:0030296 [protein tyrosine kinase activator activity]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042060 [wound healing]
GO:0042127 [regulation of cell proliferation]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043235 [receptor complex]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045087 [innate immune response]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051048 [negative regulation of secretion]
GO:0051402 [neuron apoptotic process]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 1283 aa
141.8 kDa 		No 1
ERBB3-025
ENSP00000482073
ENST00000550828
O75812 [Direct mapping]
ErbB-3 R31; Receptor tyrosine-protein kinase erbB-3
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 81 aa
8.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.