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CYB5R4

GENERAL INFORMATION

Gene name

 CYB5R4

Gene description

 Cytochrome b5 reductase 4

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic and membranous expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA018992
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA018992

GENE INFORMATION

Gene name

 CYB5R4 (HGNC Symbol)

Synonyms

 b5+b5R, dJ676J13.1, NCB5OR

Description

 Cytochrome b5 reductase 4 (HGNC Symbol)

Entrez gene summary

 NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A; MIM 613218) and CYB5 reductase (CYB5R3; MIM 613213) (Zhu et al., 1999 [PubMed 10611283]).[supplied by OMIM, Jan 2010]

Chromosome

 6

Cytoband

 q14.2

Chromosome location (bp)

 83859643 - 83967424

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000065615 (version 83.38)

Entrez gene

 51167

UniProt

 Q7L1T6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7L1T6

Antibodypedia

 CYB5R4 antibodies

PROTEIN BROWSER
CYB5R4-001
CYB5R4-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CYB5R4-001
ENSP00000358695
ENST00000369681
Q7L1T6 [Direct mapping]
Cytochrome b5 reductase 4
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003032 [detection of oxygen]
GO:0003958 [NADPH-hemoprotein reductase activity]
GO:0004128 [cytochrome-b5 reductase activity, acting on NAD(P)H]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006739 [NADP metabolic process]
GO:0006801 [superoxide metabolic process]
GO:0016174 [NAD(P)H oxidase activity]
GO:0016491 [oxidoreductase activity]
GO:0016653 [oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor]
GO:0020037 [heme binding]
GO:0030073 [insulin secretion]
GO:0042593 [glucose homeostasis]
GO:0046677 [response to antibiotic]
GO:0046872 [metal ion binding]
GO:0048468 [cell development]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
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 521 aa
59.5 kDa 		No 0
CYB5R4-003
ENSP00000358693
ENST00000369679
A0A0A0MRM6 [Direct mapping]
Cytochrome b5 reductase 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0020037 [heme binding]
GO:0046872 [metal ion binding]
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 109 aa
12.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.