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ME1

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GENERAL INFORMATION

Gene name

 ME1

Gene description

 Malic enzyme 1, NADP(+)-dependent, cytosolic

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the plasma membrane & cytosol.

RNA cell category

 Cell line enhanced (CACO-2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved)

Additional location

 In addition localized to the Plasma membrane (approved), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA006493
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CACO-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the plasma membrane & cytosol.

Main location

 Nucleoplasm (approved)

Additional location

 Plasma membrane (approved), Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA006493 A-431 Nucleoplasm
Plasma membrane
Cytosol
HPA006493 CACO-2 Nucleoplasm
HPA006493 U-2 OS Nucleoplasm

GENE INFORMATION

Gene name

 ME1

Synonyms

Description

 Malic enzyme 1, NADP(+)-dependent, cytosolic (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 q14.2

Chromosome location (bp)

 83210389 - 83431071

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000065833 (version 83.38)

Entrez gene

 4199

UniProt

 P48163 (UniProt - Evidence at protein level)

neXtProt

 NX_P48163

Antibodypedia

 ME1 antibodies

PROTEIN BROWSER
ME1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ME1-001
ENSP00000358719
ENST00000369705
P48163 [Direct mapping]
NADP-dependent malic enzyme
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004470 [malic enzyme activity]
GO:0004471 [malate dehydrogenase (decarboxylating) (NAD+) activity]
GO:0004473 [malate dehydrogenase (decarboxylating) (NADP+) activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006108 [malate metabolic process]
GO:0006741 [NADP biosynthetic process]
GO:0008948 [oxaloacetate decarboxylase activity]
GO:0009055 [electron carrier activity]
GO:0009725 [response to hormone]
GO:0009743 [response to carbohydrate]
GO:0030145 [manganese ion binding]
GO:0043531 [ADP binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050661 [NADP binding]
GO:0051262 [protein tetramerization]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:1902031 [regulation of NADP metabolic process]
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 572 aa
64.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.