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ME1

GENERAL INFORMATION

Gene name

 ME1

Gene description

 Malic enzyme 1, NADP(+)-dependent, cytosolic

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (CACO-2)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, most abundant in adrenal gland.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA006493
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006493

GENE INFORMATION

Gene name

 ME1

Synonyms

Description

 Malic enzyme 1, NADP(+)-dependent, cytosolic (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 q14.2

Chromosome location (bp)

 83210389 - 83431071

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000065833 (version 83.38)

Entrez gene

 4199

UniProt

 P48163 (UniProt - Evidence at protein level)

neXtProt

 NX_P48163

Antibodypedia

 ME1 antibodies

PROTEIN BROWSER
ME1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ME1-001
ENSP00000358719
ENST00000369705
P48163 [Direct mapping]
NADP-dependent malic enzyme
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004470 [malic enzyme activity]
GO:0004471 [malate dehydrogenase (decarboxylating) (NAD+) activity]
GO:0004473 [malate dehydrogenase (decarboxylating) (NADP+) activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006108 [malate metabolic process]
GO:0006741 [NADP biosynthetic process]
GO:0008948 [oxaloacetate decarboxylase activity]
GO:0009055 [electron carrier activity]
GO:0009725 [response to hormone]
GO:0009743 [response to carbohydrate]
GO:0030145 [manganese ion binding]
GO:0043531 [ADP binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050661 [NADP binding]
GO:0051262 [protein tetramerization]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:1902031 [regulation of NADP metabolic process]
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 572 aa
64.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.