Cell atlas - SLC9A7 - The Human Protein Atlas

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SLC9A7

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	SLC9A7
Gene description	Solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
Protein class	Plasma proteins Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA075385
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA075385	RT4	Vesicles
	HPA075385	U-2 OS	Vesicles

GENE INFORMATION
Gene name	SLC9A7 (HGNC Symbol)
Synonyms	NHE7
Description	Solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 (HGNC Symbol)
Entrez gene summary	This gene encodes a sodium and potassium/ proton antiporter that is a member of the solute carrier family 9 protein family. The encoded protein is primarily localized to the trans-Golgi network and is involved in maintaining pH homeostasis in organelles along the secretory and endocytic pathways. This protein may enhance cell growth of certain breast tumors. This gene is part of a gene cluster on chromosome Xp11.23. A pseudogene of this gene is found on chromosome 12. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Chromosome	X
Cytoband	p11.3
Chromosome location (bp)	46599252 - 46759172
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000065923 (version 83.38)
Entrez gene	84679
UniProt	Q96T83 (UniProt - Evidence at protein level)
neXtProt	NX_Q96T83
Antibodypedia	SLC9A7 antibodies

PROTEIN BROWSER

SLC9A7-001	SLC9A7-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC9A7-001 ENSP00000330320 ENST00000328306	Q96T83 [Direct mapping] Sodium/hydrogen exchanger 7 A0A024R176 [Target identity:100%; Query identity:100%] Sodium/hydrogen exchanger Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005515 [protein binding] GO:0005802 [trans-Golgi network] GO:0006811 [ion transport] GO:0006812 [cation transport] GO:0006814 [sodium ion transport] GO:0006885 [regulation of pH] GO:0015299 [solute:proton antiporter activity] GO:0015385 [sodium:proton antiporter activity] GO:0015386 [potassium:proton antiporter activity] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] GO:0042803 [protein homodimerization activity] GO:0055038 [recycling endosome membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	725 aa 80.1 kDa	Yes	>9
SLC9A7-201 ENSP00000480916 ENST00000616978	A0A087WXD1 [Direct mapping] Sodium/hydrogen exchanger Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006812 [cation transport] GO:0006814 [sodium ion transport] GO:0006885 [regulation of pH] GO:0015299 [solute:proton antiporter activity] GO:0015385 [sodium:proton antiporter activity] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] GO:1902600 [hydrogen ion transmembrane transport] Show all	726 aa 80.2 kDa	Yes	>9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.