Fields »
ABOUT
HELP
BLOG
SLC9A7

GENERAL INFORMATION

Gene name

 SLC9A7

Gene description

 Solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7

Protein class

 Plasma proteins
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA048938
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA048938

GENE INFORMATION

Gene name

 SLC9A7 (HGNC Symbol)

Synonyms

 NHE7

Description

 Solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 (HGNC Symbol)

Entrez gene summary

 This gene encodes a sodium and potassium/ proton antiporter that is a member of the solute carrier family 9 protein family. The encoded protein is primarily localized to the trans-Golgi network and is involved in maintaining pH homeostasis in organelles along the secretory and endocytic pathways. This protein may enhance cell growth of certain breast tumors. This gene is part of a gene cluster on chromosome Xp11.23. A pseudogene of this gene is found on chromosome 12. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

Chromosome

 X

Cytoband

 p11.3

Chromosome location (bp)

 46599252 - 46759172

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000065923 (version 83.38)

Entrez gene

 84679

UniProt

 Q96T83 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96T83

Antibodypedia

 SLC9A7 antibodies

PROTEIN BROWSER
SLC9A7-001
SLC9A7-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC9A7-001
ENSP00000330320
ENST00000328306
Q96T83 [Direct mapping]
Sodium/hydrogen exchanger 7
A0A024R176 [Target identity:100%; Query identity:100%]
Sodium/hydrogen exchanger
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005802 [trans-Golgi network]
GO:0006811 [ion transport]
GO:0006812 [cation transport]
GO:0006814 [sodium ion transport]
GO:0006885 [regulation of pH]
GO:0015299 [solute:proton antiporter activity]
GO:0015385 [sodium:proton antiporter activity]
GO:0015386 [potassium:proton antiporter activity]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0042803 [protein homodimerization activity]
GO:0055038 [recycling endosome membrane]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
GO:1902600 [hydrogen ion transmembrane transport]
Show all
 725 aa
80.1 kDa 		Yes >9
SLC9A7-201
ENSP00000480916
ENST00000616978
A0A087WXD1 [Direct mapping]
Sodium/hydrogen exchanger
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006812 [cation transport]
GO:0006814 [sodium ion transport]
GO:0006885 [regulation of pH]
GO:0015299 [solute:proton antiporter activity]
GO:0015385 [sodium:proton antiporter activity]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:1902600 [hydrogen ion transmembrane transport]
Show all
 726 aa
80.2 kDa 		Yes >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.