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ELAVL1

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GENERAL INFORMATION

Gene name

 ELAVL1

Gene description

 ELAV like RNA binding protein 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus. In addition localized to the nucleoli & cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported)

Additional location

 In addition localized to the Nucleoli (supported), Cytosol (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
CAB005256
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus. In addition localized to the nucleoli & cytosol.

Main location

 Nucleus (supported)

Additional location

 Nucleoli (supported), Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB005256 A-431 Nucleus
Cytosol
CAB005256 U-2 OS Nucleus
Nucleoli Intensity
CAB005256 U-251 MG Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 ELAVL1 (HGNC Symbol)

Synonyms

 Hua, HUR, MelG

Description

 ELAV like RNA binding protein 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 7958579 - 8445041

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000066044 (version 83.38)

Entrez gene

 1994

UniProt

 Q15717 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15717

Antibodypedia

 ELAVL1 antibodies

PROTEIN BROWSER
ELAVL1-001
ELAVL1-002
ELAVL1-004
ELAVL1-005
ELAVL1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ELAVL1-001
ENSP00000385269
ENST00000407627
Q15717 [Direct mapping]
ELAV-like protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0003729 [mRNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007275 [multicellular organismal development]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0017091 [AU-rich element binding]
GO:0019901 [protein kinase binding]
GO:0035925 [mRNA 3'-UTR AU-rich region binding]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0045727 [positive regulation of translation]
GO:0048255 [mRNA stabilization]
GO:0070935 [3'-UTR-mediated mRNA stabilization]
GO:2000036 [regulation of stem cell population maintenance]
Show all
 326 aa
36.1 kDa 		No 0
ELAVL1-002
ENSP00000472197
ENST00000596459
Q15717 [Direct mapping]
ELAV-like protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0003729 [mRNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007275 [multicellular organismal development]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0017091 [AU-rich element binding]
GO:0019901 [protein kinase binding]
GO:0035925 [mRNA 3'-UTR AU-rich region binding]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0045727 [positive regulation of translation]
GO:0048255 [mRNA stabilization]
GO:0070935 [3'-UTR-mediated mRNA stabilization]
GO:2000036 [regulation of stem cell population maintenance]
Show all
 326 aa
36.1 kDa 		No 0
ELAVL1-004
ENSP00000471011
ENST00000596154
M0R055 [Direct mapping]
ELAV-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
Show all
 133 aa
14.9 kDa 		No 0
ELAVL1-005
ENSP00000470727
ENST00000593807
M0QZR9 [Direct mapping]
ELAV-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
Show all
 153 aa
17.1 kDa 		No 0
ELAVL1-201
ENSP00000264073
ENST00000351593
Q15717 [Direct mapping]
ELAV-like protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0003729 [mRNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007275 [multicellular organismal development]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0017091 [AU-rich element binding]
GO:0019901 [protein kinase binding]
GO:0035925 [mRNA 3'-UTR AU-rich region binding]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0045727 [positive regulation of translation]
GO:0048255 [mRNA stabilization]
GO:0070935 [3'-UTR-mediated mRNA stabilization]
GO:2000036 [regulation of stem cell population maintenance]
Show all
 326 aa
36.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.