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ELAVL1

GENERAL INFORMATION

Gene name

 ELAVL1

Gene description

 ELAV like RNA binding protein 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA046298 , CAB005256
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (favourable).
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA046298
CAB005256

GENE INFORMATION

Gene name

 ELAVL1 (HGNC Symbol)

Synonyms

 Hua, HUR, MelG

Description

 ELAV like RNA binding protein 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 7958579 - 8445041

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000066044 (version 83.38)

Entrez gene

 1994

UniProt

 Q15717 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15717

Antibodypedia

 ELAVL1 antibodies

PROTEIN BROWSER
ELAVL1-001
ELAVL1-002
ELAVL1-004
ELAVL1-005
ELAVL1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ELAVL1-001
ENSP00000385269
ENST00000407627
Q15717 [Direct mapping]
ELAV-like protein 1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0003729 [mRNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007275 [multicellular organismal development]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0017091 [AU-rich element binding]
GO:0019901 [protein kinase binding]
GO:0035925 [mRNA 3'-UTR AU-rich region binding]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0045727 [positive regulation of translation]
GO:0048255 [mRNA stabilization]
GO:0070935 [3'-UTR-mediated mRNA stabilization]
GO:2000036 [regulation of stem cell population maintenance]
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 326 aa
36.1 kDa 		No 0
ELAVL1-002
ENSP00000472197
ENST00000596459
Q15717 [Direct mapping]
ELAV-like protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0003729 [mRNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007275 [multicellular organismal development]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0017091 [AU-rich element binding]
GO:0019901 [protein kinase binding]
GO:0035925 [mRNA 3'-UTR AU-rich region binding]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0045727 [positive regulation of translation]
GO:0048255 [mRNA stabilization]
GO:0070935 [3'-UTR-mediated mRNA stabilization]
GO:2000036 [regulation of stem cell population maintenance]
Show all
 326 aa
36.1 kDa 		No 0
ELAVL1-004
ENSP00000471011
ENST00000596154
M0R055 [Direct mapping]
ELAV-like protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
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 133 aa
14.9 kDa 		No 0
ELAVL1-005
ENSP00000470727
ENST00000593807
M0QZR9 [Direct mapping]
ELAV-like protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
Show all
 153 aa
17.1 kDa 		No 0
ELAVL1-201
ENSP00000264073
ENST00000351593
Q15717 [Direct mapping]
ELAV-like protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0003729 [mRNA binding]
GO:0003730 [mRNA 3'-UTR binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007275 [multicellular organismal development]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0017091 [AU-rich element binding]
GO:0019901 [protein kinase binding]
GO:0035925 [mRNA 3'-UTR AU-rich region binding]
GO:0043488 [regulation of mRNA stability]
GO:0044822 [poly(A) RNA binding]
GO:0045727 [positive regulation of translation]
GO:0048255 [mRNA stabilization]
GO:0070935 [3'-UTR-mediated mRNA stabilization]
GO:2000036 [regulation of stem cell population maintenance]
Show all
 326 aa
36.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.