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SMARCD1

GENERAL INFORMATION

Gene name

 SMARCD1

Gene description

 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA004101
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA004101

GENE INFORMATION

Gene name

 SMARCD1 (HGNC Symbol)

Synonyms

 BAF60A, CRACD1, Rsc6p

Description

 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.12

Chromosome location (bp)

 50084972 - 50100712

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000066117 (version 83.38)

Entrez gene

 6602

UniProt

 Q96GM5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96GM5

Antibodypedia

 SMARCD1 antibodies

PROTEIN BROWSER
SMARCD1-001
SMARCD1-002
SMARCD1-004
SMARCD1-010
SMARCD1-011
SMARCD1-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SMARCD1-001
ENSP00000378414
ENST00000394963
Q96GM5 [Direct mapping]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006337 [nucleosome disassembly]
GO:0006338 [chromatin remodeling]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007399 [nervous system development]
GO:0016514 [SWI/SNF complex]
GO:0032947 [protein complex scaffold]
GO:0048096 [chromatin-mediated maintenance of transcription]
GO:0071398 [cellular response to fatty acid]
GO:0071564 [npBAF complex]
GO:0071565 [nBAF complex]
GO:0090544 [BAF-type complex]
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 515 aa
58.2 kDa 		No 0
SMARCD1-002
ENSP00000370924
ENST00000381513
Q96GM5 [Direct mapping]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0006337 [nucleosome disassembly]
GO:0006338 [chromatin remodeling]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007399 [nervous system development]
GO:0016514 [SWI/SNF complex]
GO:0032947 [protein complex scaffold]
GO:0048096 [chromatin-mediated maintenance of transcription]
GO:0071564 [npBAF complex]
GO:0071565 [nBAF complex]
Show all
 474 aa
53.3 kDa 		No 0
SMARCD1-004
ENSP00000449825
ENST00000551497
F8VW95 [Direct mapping]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 113 aa
12.8 kDa 		No 0
SMARCD1-010
ENSP00000448030
ENST00000550477
F8VUB0 [Direct mapping]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 290 aa
32.1 kDa 		No 0
SMARCD1-011
ENSP00000447386
ENST00000551966
F8VZ70 [Direct mapping]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 278 aa
30.3 kDa 		No 0
SMARCD1-012
ENSP00000448627
ENST00000548573
F8VRQ4 [Direct mapping]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 313 aa
36.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.