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KDM4A

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GENERAL INFORMATION

Gene name

 KDM4A

Gene description

 Lysine (K)-specific demethylase 4A

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoli (fibrillar center).

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoli fibrillar center (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA007610
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoli (fibrillar center).

Main location

 Nucleoli fibrillar center (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA007610 A-431 Nucleoli fibrillar center
Cytosol
HPA007610 U-2 OS Nucleoli fibrillar center
HPA007610 U-251 MG Nucleoli fibrillar center

GENE INFORMATION

Gene name

 KDM4A (HGNC Symbol)

Synonyms

 JHDM3A, JMJD2, JMJD2A, KIAA0677, TDRD14A

Description

 Lysine (K)-specific demethylase 4A (HGNC Symbol)

Entrez gene summary

 This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009]

Chromosome

 1

Cytoband

Chromosome location (bp)

 43650158 - 43705515

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000066135 (version 83.38)

Entrez gene

 9682

UniProt

 O75164 (UniProt - Evidence at protein level)

neXtProt

 NX_O75164

Antibodypedia

 KDM4A antibodies

PROTEIN BROWSER
KDM4A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KDM4A-001
ENSP00000361473
ENST00000372396
O75164 [Direct mapping]
Lysine-specific demethylase 4A
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005721 [pericentric heterochromatin]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0010507 [negative regulation of autophagy]
GO:0010629 [negative regulation of gene expression]
GO:0014898 [cardiac muscle hypertrophy in response to stress]
GO:0016032 [viral process]
GO:0016577 [histone demethylation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032452 [histone demethylase activity]
GO:0035064 [methylated histone binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0051864 [histone demethylase activity (H3-K36 specific)]
GO:0055114 [oxidation-reduction process]
GO:0070544 [histone H3-K36 demethylation]
GO:1900113 [negative regulation of histone H3-K9 trimethylation]
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 1064 aa
120.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.